Clinical Studies


A Randomized, Double-Blind, Placebo Controlled, Multicenter, Parallel Group Study To Evaluate The Efficacy And Safety Of Brivarecetam In Subjects (>/= 16 TO 80 Years Old) With Partial Onset Seizures

Study to Evaluate Efficacy and Safety of Perampanel as Monotherapy or First Adjunctive Therapy in Subjects W/Partial Onset Seizures W/ or Without Secondarily Generalized Seizures or W/ Primary Generalized Tonic-Clonic Seizures


A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study Exploring the Efficacy, Safety, and Tolerability of Natalizumab (BG00002) as Adjunctive Therapy in Adult Subjects With Drug-Resistant Focal Epilepsy


Digital Epilepsy Management: The Use of a Two-way Communication Platform to Collect Patient-Entered Data as a Diagnostic Aid in the Newly Diagnosed and Refractory Population 



Study to Collect Information on Safety and to Document Drug Utilization of Tecfidera™ (Dimethyl Fumarate) When Used in Routine Medical Practice in Treatment of Multiple Sclerosis (ESTEEM)

 A Phase III, Multicenter, Randomized, Parallel Group, Double Blind, Double Dummy, Active Controlled Study of Evobrutinib Compared with Teriflunomide, in Participants with Relapsing Multiple Sclerosis to Evaluate Efficacy and Safety.  MS200527ˍ0080



H8H-MC-LAHV(a) Pediatric Options for Migraine Relief: A Randomized, Double-Blind, Placebo-Controlled Study of Lasmiditan for Acute Treatment of Migraine: PIONEER-PEDS1

A Phase 3, 12-Month, Open-Label Study of Lasmiditan in Pediatric Patients with Migraine - PIONEER-PEDS2

A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel Group Study to Evaluate the Efficacy and Safety of SPN-538 as a Therapy for the Prevention of Migraine in Subjects Ages 6-11 Years

A Phase I, Randomized, Open-label, Multiple-dose Study to Evaluate Safety, Tolerability, and Pharmacokinetics of AMG 334 in Children and Adolescents with Migraine


Parkinson’s Disease:

A Randomized, Double-Blind, Double-Dummy, Active-Controlled Study Comparing the Efficacy, Safety and Tolerability of ABBV-951 to Oral Carbidopa/Levodopa in Advanced Parkinson's Disease Patients

Phase 2b/3, Randomized, Double-blind, Placebo-controlled, Parallel Group, Multicenter Study to Evaluate the Safety and Efficacy of Dipraglurant (ADX48621) for the Treatment of Dyskinesia in Patients with Parkinson's Disease Receiving Levodopa-based Therapy with or without Concomitant Dopaminergic Medications

Evaluation of the Personal KinetiGraph™ (PKG™) to Improve Insight into Parkinson’s Disease Status (APPRISE)


Brain-Derived Neurotrophic Factor Precision Medicine for Parkinson’s Disease – Levodopa Study (BDNF-LD)


A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, 27-Week Trial to Evaluate the Efficacy, Safety, and Tolerability of Two Fixed Doses of Tavapadon in Early Parkinson’s Disease (TEMPO-1 TRIAL)


An Open-Label, Phase 3 StudyExamining theLong-TermSafety,Tolerability and Efficacyof APL-130277 in LevodopaResponsivePatients withParkinsonsDisease Complicated by Motor Fluctuations(“OFF”Episodes)


A Randomized Controlled Study to Compare the Safety and Efficacy of IPX203 With Immediate–Release Carbidopa-Levodopa in Parkinson’s Disease Patients With Motor Fluctuations.


A Multicenter, Randomized, Active-Controlled, Double-Blind, Double Dummy, Parallel Group Clinical Trial, Investigating the Efficacy, Safety, and Tolerability of Continuous Subcutneous ND0612 Infusion in Comparison to Oral IR-LD/CD in Subjects With Parkinson’s Disease Experiencing Motor Fluctuations (BouNDless


A Phase 3, Twelve-week, Multi-Center, Multinational, Randomized, Double-Blind, Double-Dummy, Parallel Group Study to Determine the Efficacy, Safety, and Tolerability of P2B001 Once Daily Compared to its Individual Components in Subjects With Early Parkinson’s Disease and to a Calibration Arm of Pramipexole ER


A Randomized,PlaceboSurgeryControlled,Double-blinded,Multi-center,Phase2ClinicalTrial,EvaluatingtheEfficacyandSafety ofVY-AADC02inAdvancedParkinson’sDiseasewithMotorFluctuations(ShortTitle:AADCinAdvancedPDTrial–ADAPT)


A Multi-Center, Prospective, Longitudinal, Digital Assessment Study of Disease Progression in Subjects with Early, Untreated Parkinson Disease (PD)


Management of Parkinson’s Disease Psychosis in Actual Practice (The INSYTE Study)


Utilization of Target Ranges to Treat Persons with Parkinson’s Disease by Objective Measurement Using the Personal KinetiGraph® (PKG®) compared to Standard of Care Assessment (TARGET-PwP)- A Randomized Controlled Trial


Alzheimer’s Disease:

A Placebo-controlled, Double-blind, Parallel-group, Bayesian Adaptive Randomization Design and Dose Regimen-finding Study to Evaluate Safety, Tolerability and Efficacy of BAN2401 in Subjects With Early Alzheimer’s Disease


Myasthenia Gravis:  

A Phase 2, Randomized, Placebo-Controlled Study to Evaluate Safety, Tolerability, and Efficacy of TAK-079 in Patients With Generalized Myasthenia Gravis


A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Confirm the Efficacy, Safety, and Tolerability of Zilucoplan in Subjects with Generalized Myasthenia Gravis


A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Safety and Efficacy of Ravulizumab in Complement-Inhibitor-Naïve Adult Patients With Generalized Myasthenia Gravis


Long-Term, Observational, Registry of Patients With Generalized Myasthenia Gravis Who Have Received Treatment With Complement C5 Inhibition Therapies



 A Phase 2 Trial to Investigate the Efficacy, Safety, and Tolerability of Efgartigimod PH20 SC in Adult Patients with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) (ADHERE)


Cervical Dystonia:  


A Phase 3, Open-Label, Multi-Center Trial to Evaluate the Long-Term Safety and Efficacy of Repeat Treatments of DaxibotulinumtoxinA for Injection in Adults with Isolated Cervical Dystonia (ASPEN-OLS)


Investigator Initiated:  

Characteristics of Ocular Myasthenia Gravis


Optical Coherence Tomography and Cervical Dystonia: Is there a link between the retina and an isolated focal dystonia that is disease specific?  


Short and Long Term Outcomes of an Outpatient Physical Therapy Protocol for the Treatment of Functional Movement Disorders


Localization of vergence centers using functional MRI


Does Light Exposure Impact Seizure Frequency? Testing a Hypothesis


International research:

Distal Symmetric Polyneuropathies in Zambia

Research on Assessments of Vitamin B12 and Evaluation of Neurological Symptoms in Zambia (RAVENS)


Acute Paralysis Prevalence & Etiologies in Lusaka, Zambia (APPEL)


Community Health and Neuropathies in Zambia


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