Dr. Larry Charleston, IV, graduated in Medicine from the Wayne State University School of Medicine in Detroit, Michigan. He then completed his internship in internal medicine at St. John Hospital and Medical Center in Detroit, Michigan and neurology residency at Baylor College of Medicine in Houston, Texas. After residency training, he completed his Headache and Facial Pain fellowship at the Thomas Jefferson Headache Center in Philadelphia, Pennsylvania. Dr. Charleston is certified in Adult Neurology by the American Board of Psychiatry and Neurology (ABPN) and Headache Medicine by the United Council of Neurological Subspecialties (UCNS). He received his MS degree in Health and Health Care Research from the National Clinical Scholars Program at the University of Michigan in Ann Arbor, Michigan in 2017. He joined the Department of Neurology at Michigan State University in March 2021.
Academic Appointments
Assistant Clinical Professor, Michigan State University, College of Human Medicine, Grand Rapids, MI, 2011-13, Clinical Assistant Professor of Neurology, University of Michigan, Ann Arbor, MI, 2013-18, Clinical Associate Professor of Neurology, University of Michigan Ann Arbor, MI. 2018-21, Adjunct Faculty, Thomas Jefferson University, Philadelphia, PA, 2020-present, Professor of Neurology, Michigan State University College of Human Medicine, East Lansing, MI, 2021-present, Director, Headache Medicine and Facial Pain, Director, Department Faculty Development
Education
- M.D., Wayne State University School of Medicine, 2001-2005
- MS, Health and Health Care Research, National Clinical Scholars Program, University of Michigan, 2015-2017
Postdoctoral Training
Internship, Internal Medicine, St. John Hospital and Medical Center, Detroit, MI, 2005-2006, Residency, Neurology, Baylor College of Medicine, Houston, TX, 2006-2009, Fellowship, Headache and Facial Pain, Jefferson Headache Center, Philadelphia, PA, 2009-10
Publications
- Charleston L 4th, Savage-Edwards B, Bragg SM, Baygani SK, Dennehy EB. Migraine history and response to lasmiditan across racial and ethnic groups. Curr Med Res Opin. 2022 Apr 3:1-10. doi: 10.1080/03007995.2022.2057152. Epub ahead of print. PMID: 35350937
- VanderPluym JH, Charleston L 4th, Stitzer ME, Flippen CC 2nd, Armand CE, Kiarashi J. A Review of Underserved and Vulnerable Populations in Headache Medicine in the United States: Challenges and Opportunities. Curr Pain Headache Rep. 2022 Mar 26. doi: 10.1007/s11916-022-01042-w. Epub ahead of print. PMID: 35347652.
- Buse DC, Winner PK, Charleston L 4th, Hirman J, Cady R, Brevig T. Early response to eptinezumab indicates high likelihood of continued response in patients with chronic migraine. J Headache Pain. 2022 Feb 21;23(1):29. doi: 10.1186/s10194-022-01387-y. PMID: 35189811; PMCID: PMC8903499
- Lipton RB, Charleston L 4th, Tassorelli C, Brevig T, Hirman J, Cady R. Patient-reported outcomes, health-related quality of life, and acute medication use in patients with a ≥ 75% response to eptinezumab: subgroup pooled analysis of the PROMISE trials. J Headache Pain. 2022 Feb 7;23(1):23. doi: 10.1186/s10194-022-01386-z. PMID: 35130836; PMCID: PMC8903490
- Minen M., Khanns D., Guiacocha J., Ehrlich A., Khan FA. Ashhar A., Birlea M., Singh N., Peretz A., Charleston L 4th.: The Role of Urgent Care Centers in Headache Management. BMC Health Serv Res 22, 162 (2022)
- Reynolds, E; Burke, J; Evans, L; Syed, F; Liao, E; Lobo, R; Cooper, W; Charleston 4th, L; Callaghan, B.: Headache neuroimaging: a survey of current practice, barriers, and facilitators to optimal use. Headache. 2022 Jan;62(1):36-56. doi: 10.1111/head.14249. PMID: 35041218.
- Halker Singh RB, Bobker SM, Roberts JL, Charleston L. 4th, Robbins MS, Pradhan A, Sprenger T, Poso-Rosich P, Orr SL, Powers SW, Houle TT, Turner DP, Gelfand AA. Advancing our commitment to our peer reviewers. Headache. 2021 Oct 13. Epub ahead of print.
- Charleston L. 4th, Halker Singh RB. Virtual issue: Diversity, equity, and inclusion. Headache. 2021 Sep 23. doi: 10.1111/head.14209. Epub ahead of print. PMID: 34553770
- Charleston L 4th, Ovbiagele B. Diversity in neurology leadership: Nuances and nudges. J Neurol Sci. 2021 Jul 15;426:117475. doi: 10.1016/j.jns.2021.117475. Epub 2021 May 3. PMID: 33965794.
- Buse DC, Armand CE, Charleston L 4th, Reed ML, Fanning KM, Adams AM, Lipton RB. Barriers to care in episodic and chronic migraine: Results from the Chronic Migraine Epidemiology and Outcomes Study. Headache. 2021 Apr;61(4):628-641. doi: 10.1111/head.14103. Epub 2021 Apr 1. PMID: 33797078.
- Begasse de Dhaem O, Kiarashi J, Armand CE, Charleston L 4th, Szperka CL, Lee YS, Rajapakse T, Seng EK, VanderPluym JH, Starling AJ. Ten Eleven things to facilitate participation of underrepresented groups in headache medicine research. Headache. 2021 Jun;61(6):951-960. doi: 10.1111/head.14124. Epub 2021 Jun 14. PMID: 34125956.
- Kiarashi J, VanderPluym J, Szperka CL, Turner S, Minen M, Broner S, Ross AC, Wagstaff AE, Anto M, Marzouk M, Monteith Tj, Rosen N, Manrriquez SL, Seng E, Finkel A, Charleston L. 4th: Headache Factors Associated with, and Mitigation Strategies for Healthcare Disparities Faced by Patients with Headache Disorders. Neurology. 2021 Jun 9:10.1212/WNL.0000000000012261. doi: 10.1212/WNL.0000000000012261. Epub ahead of print. PMID: 34108270.
- Charleston L 4th, Khalil S, Young WB. Carnitine Responsive Migraine Headache Syndrome: Case Report and Review of the Literature. Curr Pain Headache Rep. 2021 Mar 23;25(4):26. doi: 10.1007/s11916-021-00936-5. PMID: 33755806
- Charleston L. 4th: Headache Disparities in African Americans: A narrative review and response to the National Institute of Neurological Disorders and Stroke Request for information on Neurological Disparities in the United States Journal of the National Medical Association. (In Press) PMID: 33160641
- Charleston L. 4th, Spears, RC: Equity of African-American Men in Headache in the United States: a perspective from African American Headache Medicine Specialists. Part 2 Headache: The Journal of Head & Face Pain 0: 1-9, 2020. PMID: 33141447
- Charleston L. 4th, Spears RC, Flippen CC.: Equity of African-American Men in Headache in the United States: a perspective from African American Headache Medicine Specialists. Part 1 Headache: The Journal of Head & Face Pain 0: 1-13, 2020. PMID: 33140448
- Charleston L. 4th, Cooper, W: An Update on Idiopathic Hypertrophic Cranial Pachymeningitis for the Headache Practitioner Current Headache and Pain Reports 24 (10): 57, 2020. 32803475
- Charleston, L. 4th: Cross-Cultural Headache Care Within the United States: Speaking the Unspoken Language Headache the Journal of Head and Face Pain 0: 1-5, 2020. PM32535945
Abstracts
- Charleston L 4th, Cohen JM, Ning X, Campos VR, Rarash S. Lengil T, Kim B. Safety and Efficacy of Fremanezumab in Different Racial and Ethnic Subgroups of Patients With Migraine: A Pooled Analysis of Phase 3 Studies. 2022 American Academy of Neurology Annual Meeting, 2022
- Lipton RB, Charleston L 4th, Tassorelli C, Brevig T, Hirman J, Cady R.: Patients with Migraine Who Achieved a ≥75% Reduction in Monthly Migraine Days with Eptinezumab Treatment: Subgroup Analysis of PROMISE-1 and PROMISE-2. 2022 Diamond Headache Winter Conference
- Charleston L 4th, Campos VR, Ning X, Krasenbaum L, Janka L, Kessler Y, Nahas S. Six-month Safety and Efficacy of Fremanezumab in Migraine: Pooled Analysis from Phase 3 FOCUS and HALO Trials. 2022 American Academy of Neurology Annual Meeting, 2022
- Charleston L 4th, Cohen JM, Ning X, Campos VR, Rarash S. Lengil T, Kim B. Pooled Analysis of Safety and Efficacy of Fremanezumab in Different Racial and Ethnic Subgroups of Patients With Migraine. 2021 International Headache Congress Meeting, 2021
- Lipton RB, Charleston L 4th, Tassorelli C, Brevig T, Hirman J, Cady R.: Patients with Migraine Who Achieved a ≥75% Reduction in Monthly Migraine Days with Eptinezumab Treatment: Subgroup Analysis of PROMISE-1 and PROMISE-2, 2021 International Headache Congress Meeting, 2021
- Underrepresented in Medicine: Identifying Representation in Neurology Subspecialty Society Recognition Awards. Anne Koronkiewicz, DO1* Alexandra Below, DO1* Alain Lekoubou, MD MS2 Bruce Ovbiagele, MD, MSc, MAS, MBA, FRCP3 Larry Charleston IV, MD, MSc, FAHS1 1 Department of Neurology, Michigan State University College of Human Medicine, East Lansing, Michigan 2 Department of Neurology, Penn State University, Hershey Medical Center, Hershey, Pennsylvania 3 Department of Neurology, University of California, San Francisco, California *Anne Koronkiewicz, DO and Alexandra Below, DO are joint first authors. American Neurological Association 2021 Meeting (Accepted)
- DEARTH OF RECOGNITION AWARDS GIVEN TO UNDERREPRESENTED IN MEDICINE INDIVIDUALS BY MAJOR US NEUROLOGICAL SOCIETIES Omolara Lawal1 * Abena Kwegyir-Aggrey1* Larry Charleston IV2 Bruce Ovbiagele3 Alain Lekoubou1 Department of Neurology, Penn State University, Hershey Medical Center, Hershey, Pennsylvania2 Department of Neurology, Michigan State University College of Human Medicine, East Lansing, Michigan 3 Department of Neurology, University of California, San Francisco * Omolara Lawal and Abena Kwegyr-Aggrey are joint first authors. American Neurological Association 2021 Meeting (Accepted)
- Charleston L 4th: Identifying and Understanding Microaggressions among Michigan Medicine African- American Faculty Members, AAN Annual Meeting, 2021.
- Minen MT, Ehrlick A, Khanns D, Guiracocha JS, Khan F, Ali A, Birlea M, Singh N, Peretz A, Charleston L 4th: What Role do Urgent Care Centers Play in Headache Management? A Quality Improvement Study of Select Urgent Care Facilities, 2021 AHS Annual Scientific Meeting, 2021.
- Lipton RB, Charleston L 4th, Tassorelli C, Brevig T, Hirman J, Cady R.: Patients with Migraine Who Achieved a ≥75% Reduction in Monthly Migraine Days with Eptinezumab Treatment: Subgroup Analysis of PROMISE-1 and PROMISE-2, 2021 AHS Annual Scientific Meeting, 2021.
- Buse DC, Winner PK, Charleston L 4th, Hirman J, Cady R, Brevig T.: Early Response to Eptinezumab Indicates High Likelihood of Continued Response with Treatment in Patients with Chronic Migraine, 2021 AHS Annual Scientific Meeting, 2021.
Presentations
- Advance Headache Diagnosis and Management Intensive Sessions: Live Case-Based Simulations, Procedures, Neuromodulation, and Mentoring. Thomas Jefferson University, Philadelphia, PA. June 25-26, 2022
- Black Headache Patients Matter: Exploration of Race, Racism, Race-Based Headache Disparities, and Professional Ethics- 2022 Seymour Solomon Award Lecture. 2022 AHS 64th Annual Scientific Meeting, Aurora, CO. June 10, 2022
- Healthcare Disparities of Migraine Disease in the African American Population. Society of Black Neurologists and AbbVie Neuroscience Roundtable Discussion. Co-moderator and Program Development Committee. (Held in conjunction with the American Academy Neurology 74th Annual Meeting). Seattle, WA. April 4, 2022
- Strategies for Personal Leadership: Developing the Leader Within. Proposal, Curriculum Developer and Program lead. American Academy of Neurology 74th Annual Meeting. Seattle, WA. April 4, 2022
- Disparities in Headache Care in the United States. Headache Cooperative of New England 32nd Stowe Headache Symposium. April 2, 2022.
- Michigan State University College of Osteopathic Medicine Summer Symposium: Toward Achieving Diversity, Equity and Inclusion in Headache Medicine: Migraine Diagnosis and A Perspective on African-American Disparities in Migraine, Traverse City, MI. June 24, 2022
- Michigan State University College of Human Medicine, Diversity Equity & Inclusion Grand Rounds: Toward Achieving Diversity, Equity and Inclusion in Headache Medicine: A Perspective on African-American Disparities in Migraine, Virtual Presentation, October 12, 2021
- Healthcare Disparities Put "Undue" Disease Burden on Patients; Contributors: Hope L. O'Brien, MD and Larry Charleston, IV, MD; Video Commentary, Medscape, November 19, 2021.
- Disparities in Headache and Migraine Care: Access Concerns, Alliance for Patient Access Headache and Migraine Workgroup Meeting, November 2020, Virtual
- Candid Conversation: Why Research Matters? bias, Beliefs and Myths. A candid discussion on headache care disparities and clinical research participation of underrepresented ethnic groups, Delta Research and Educational Foundation (DREF), November 2020, Virtual
- Embracing New Treatment Options in the Management of Migraine Headache, Continuing Education Alliance (CEA) and Practicing Clinicians Exchange (PCE), May 2020, Virtual
- Migraine Expert Advisor/Stakeholder Panel Member, PCORI Project: Non-pharmacological Modalities for Migraine Prevention Mapping Project, ECRI Institute Evidence Practice-Based Practice Center for Clinical Excellence and Guidelines, April 2021, US
Funding/Grants
- Diversity in Headache Advisory Council (DiHAC) Grant: Identifying and strengthening headache literacy knowledge domain of migraine diagnosis and disparities in underrepresented in medicine medical students and communities; Diversity in Headache Advisory Council (DiHAC) Grant, 2/2021-07/2022
- Amgen Competitive Grant in Migraine: Feasibility of a text messaging intervention to enhance self-management behaviors in patients with migraine. Charleston, L. 4th, PI 05/2022-11/2023.
Research Interests
Headache and Facial Pain Treatment Interventions
Headache and Facial Pain Education
Headache Care/Neurological Disparities in Underrepresented Ethnic Groups/Cross-Cultural Sensitivity and Literacy
Health Care Policy and Advocacy
The Use of Nutraceuticals in Migraine Prevention
Peripheral Nerve Blocks and Other Interventional Procedures for Headache and Management
Clinical Interests
Headache and Facial Pain Treatment, Comprehensive Plan Development and Therapeutic Interventions.
Awards
Recipient of the 2022 American Headache Society's Seymour Solomon, MD Lecture Award, Selected American Academy of Neurology 2021 Headache Medicine NeuroBytes Champion, 2020-present, Abstract of Distinction Merit Award, 2021 American Academy of Neurology, 2021 Virtual Meeting, Top Neurologist 2020, Nomination
Certifications
American Board of Psychiatry and Neurology, Adult Neurology, United Council of Neurological Subspecialties, Headache Medicine
Fellowships
Fellowship, Headache and Facial Pain, Jefferson Headache Center, Philadelphia, PA, 2009-10
Memberships
Member, Clinical Neurological Society of America, 2021-present, Member, National Medical Society, 2020-present, Member, American Academy of Neurology (AAN), 2018-present, Member, University of Michigan's Institute for Healthcare Policy and Innovation, 2016-present, Member, American Neurological Association, 2015-present, Member, International Headache Society, 2013-present, Member, National Headache Foundation, 2012-present, Member, American Headache Society, 2011-present