Dr. Larry Charleston, IV, graduated in Medicine from the Wayne State University School of Medicine in Detroit, Michigan. He then completed his internship in internal medicine at St. John Hospital and Medical Center in Detroit, Michigan and neurology residency at Baylor College of Medicine in Houston, Texas. After residency training, he completed his Headache and Facial Pain fellowship at the Thomas Jefferson Headache Center in Philadelphia, Pennsylvania. Dr. Charleston is certified in Adult Neurology by the American Board of Psychiatry and Neurology (ABPN) and Headache Medicine by the United Council of Neurological Subspecialties (UCNS). He received his MS degree in Health and Health Care Research from the National Clinical Scholars Program at the University of Michigan in Ann Arbor, Michigan in 2017. He joined the Department of Neurology at Michigan State University in March 2021.
Academic Appointments
Assistant Clinical Professor, Michigan State University, College of Human Medicine, Grand Rapids, MI, 2011-13, Clinical Assistant Professor of Neurology, University of Michigan, Ann Arbor, MI, 2013-18, Clinical Associate Professor of Neurology, University of Michigan Ann Arbor, MI. 2018-21, Adjunct Faculty, Thomas Jefferson University, Philadelphia, PA, 2020-present, Professor of Neurology, Michigan State University College of Human Medicine, East Lansing, MI, 2021-present, Director, Headache Medicine and Facial Pain, Director, Department Faculty Development
Education
- M.D., Wayne State University School of Medicine, 2001-2005
- MS, Health and Health Care Research, National Clinical Scholars Program, University of Michigan, 2015-2017
Postdoctoral Training
Internship, Internal Medicine, St. John Hospital and Medical Center, Detroit, MI, 2005-2006, Residency, Neurology, Baylor College of Medicine, Houston, TX, 2006-2009, Fellowship, Headache and Facial Pain, Jefferson Headache Center, Philadelphia, PA, 2009-10
Publications
- Charleston L 4th. Developing and Delivering a Migraine Disparities and Diagnosis Undergraduate Medical Educational Program to Underrepresented in Medicine Medical Student Members of the Student National Medical Association: A Pilot Project. Headache 2024, pending
- Charleston L 4th, Posas J. Categorizing Sports-Related Concussion Disparities by Key Domains of Social Determinants of Health. Curr Pain Headache Rep. 2024 Jan 16, PMID: 38227210
- Charleston L 4th, Talon B,. Sullivan C., Kymes S., Regnier SA., Soni-Brehnbhatt S., Nahas SJ. Persistence to onabotulinumtoxinA and anti-CGRP monoclonal antibody therapy among patients with migraine: a retrospective cohort study. J Headache Pain, 2023 Aug 2:24(1):101, PMID: 37532991
- Herne, MM, Charleston, L. Insight of a Headache Medicine provider in the Indian Health Services: A Personal and Professional Observation. Headache, 2023 May, 63(5):697-699. PMID: 37171379
- Charleston, L 4th. Is headache equity an emergency (visit)? Learning from an emergency department utilization study. Headache, 2023 April, 63(4):459-460. PMID: 37036179
- Charleston L 4th, Savage-Edwards B, Bragg SM, Baygani SK, Dennehy EB. Migraine history and response to lasmiditan across racial and ethnic groups. Curr Med Res Opin. 2022 Apr 3:1-10. doi: 10.1080/03007995.2022.2057152. Epub ahead of print. PMID: 35350937
- VanderPluym JH, Charleston L 4th, Stitzer ME, Flippen CC 2nd, Armand CE, Kiarashi J. A Review of Underserved and Vulnerable Populations in Headache Medicine in the United States: Challenges and Opportunities. Curr Pain Headache Rep. 2022 Mar 26. doi: 10.1007/s11916-022-01042-w. Epub ahead of print. PMID: 35347652.
- Buse DC, Winner PK, Charleston L 4th, Hirman J, Cady R, Brevig T. Early response to eptinezumab indicates high likelihood of continued response in patients with chronic migraine. J Headache Pain. 2022 Feb 21;23(1):29. doi: 10.1186/s10194-022-01387-y. PMID: 35189811; PMCID: PMC8903499
- Lipton RB, Charleston L 4th, Tassorelli C, Brevig T, Hirman J, Cady R. Patient-reported outcomes, health-related quality of life, and acute medication use in patients with a ≥ 75% response to eptinezumab: subgroup pooled analysis of the PROMISE trials. J Headache Pain. 2022 Feb 7;23(1):23. doi: 10.1186/s10194-022-01386-z. PMID: 35130836; PMCID: PMC8903490
- Minen M., Khanns D., Guiacocha J., Ehrlich A., Khan FA. Ashhar A., Birlea M., Singh N., Peretz A., Charleston L 4th.: The Role of Urgent Care Centers in Headache Management. BMC Health Serv Res 22, 162 (2022)
- Reynolds, E; Burke, J; Evans, L; Syed, F; Liao, E; Lobo, R; Cooper, W; Charleston 4th, L; Callaghan, B.: Headache neuroimaging: a survey of current practice, barriers, and facilitators to optimal use. Headache. 2022 Jan;62(1):36-56. doi: 10.1111/head.14249. PMID: 35041218.
- Halker Singh RB, Bobker SM, Roberts JL, Charleston L. 4th, Robbins MS, Pradhan A, Sprenger T, Poso-Rosich P, Orr SL, Powers SW, Houle TT, Turner DP, Gelfand AA. Advancing our commitment to our peer reviewers. Headache. 2021 Oct 13. Epub ahead of print.
- Charleston L. 4th, Halker Singh RB. Virtual issue: Diversity, equity, and inclusion. Headache. 2021 Sep 23. doi: 10.1111/head.14209. Epub ahead of print. PMID: 34553770
- Charleston L 4th, Ovbiagele B. Diversity in neurology leadership: Nuances and nudges. J Neurol Sci. 2021 Jul 15;426:117475. doi: 10.1016/j.jns.2021.117475. Epub 2021 May 3. PMID: 33965794.
- Buse DC, Armand CE, Charleston L 4th, Reed ML, Fanning KM, Adams AM, Lipton RB. Barriers to care in episodic and chronic migraine: Results from the Chronic Migraine Epidemiology and Outcomes Study. Headache. 2021 Apr;61(4):628-641. doi: 10.1111/head.14103. Epub 2021 Apr 1. PMID: 33797078.
- Begasse de Dhaem O, Kiarashi J, Armand CE, Charleston L 4th, Szperka CL, Lee YS, Rajapakse T, Seng EK, VanderPluym JH, Starling AJ. Ten Eleven things to facilitate participation of underrepresented groups in headache medicine research. Headache. 2021 Jun;61(6):951-960. doi: 10.1111/head.14124. Epub 2021 Jun 14. PMID: 34125956.
- Kiarashi J, VanderPluym J, Szperka CL, Turner S, Minen M, Broner S, Ross AC, Wagstaff AE, Anto M, Marzouk M, Monteith Tj, Rosen N, Manrriquez SL, Seng E, Finkel A, Charleston L. 4th: Headache Factors Associated with, and Mitigation Strategies for Healthcare Disparities Faced by Patients with Headache Disorders. Neurology. 2021 Jun 9:10.1212/WNL.0000000000012261. doi: 10.1212/WNL.0000000000012261. Epub ahead of print. PMID: 34108270.
- Charleston L 4th, Khalil S, Young WB. Carnitine Responsive Migraine Headache Syndrome: Case Report and Review of the Literature. Curr Pain Headache Rep. 2021 Mar 23;25(4):26. doi: 10.1007/s11916-021-00936-5. PMID: 33755806
Abstracts
- Schwedt TJ, Pradhan AA, Oshinsky ML, Brin MF, Rosen H, Lalvani N, Charles A, Ashina M, Do TP, Burstein R, Gelfand AA, Dodick DW, Pozo-Rosich P, Lipton RB, Ailani J, Szperka C, Charleston 4th L, Digre KB, Russo AF, Buse DC, Powers S, Tassorelli C, Goadsby PJ. The Headache Research Priorities: Consensus Recommendations from the American Headache Society, the National Institute of Neurological Disorders and Stroke, and an International Multistakeholder Expert Group. American Headache Society Scientific Meeting, 2024.
- Charleston L. 4th, Strom S, Albrecht, D, Cowan R. STS101 Demonstrated Long- Term Clinical Benefit in the Phase 3 Open-Label ASCEND Study. American Headache Society Scientific Meeting, 2024.
- Ailani J., Charleston L. 4th, Strom S., Albrecht D. Subjects View Use of STS101 Favorably: Subject Impression Data From the Phase 3 Open- Label ASCEND Study. American Headache Society Scientific Meeting
- Charleston L. 4th, Richard-Lee C. Red Ear Syndrome. A Case of a Rare Disease with Unusual Findings. American Headache Society Scientific Meeting, 2024.
- Efficacy and Safety of Rimegepant for the Acute Treatment of Migraine in Black and African American Adults: Results From 3 Randomized, Placebo- Controlled Clinical Trials. Headache Cooperative of the Pacific (HCOP) Winter Meeting 2024.
- Charleston L. 4th, Nahas S, Rieckmann A, Regnier SA, Fiore D, Sullivan C, Grossman S, Talon B. Migraine Prevention: A Retrospective Cohort Claims Database Study. (Accepted – Bronze Ribbon Award Recipient. AMCP Managed Care & Specialty Pharmacy, 2024
- Blumenfeld A. Charleston L 4th, Summer K, O’Brien HL. Efficacy of OnabotulinumtoxinA Among Diverse Racial/Ethnic Groups: Post hoc Analysis of the Phase 4 COMPEL Trial, European Headache Federation Congress, 2023.
- Charleston L. Migraine Disparities and Diagnosis Undergraduate Medical Educational Program to Underrepresented In Medicine Medical Student Members of the Student National Medical Association. American Neurological Association Meeting, 2023.
- Charleston L. 4th, Talon B., Sullivan C., Anderson C., Kymes S., Regnier SA., Soni- Brehnbhatt S., Nahas SJ. Persistence to onabotulinumtoxinA and anti- CGRP monoclonal antibody therapy among patients with migraine: a retrospective cohort study. American Headache Society Scientific Meeting, 2023.
- Charleston L. 4th, Starling A., Tariq N. Transnasal Evaporative Cooling Device for Migraine: A Randomized Trial, American Headache Society Scientific Meeting, 2023.
- Charleston L. 4th, Armand CE, Helveston WR, Monteith TS, O'Brien HL, Croop R., Alexandra Thiry A., Morris BA, Forshaw M., Abbott CC. Rimegepant for the Acute Treatment of Migraine in Black and African American Adults: Results From 3 Randomized, Placebo- Controlled Clinical Trials. American Headache Society Scientific Meeting, 2023.
- Charleston L. 4th. Developing and Delivering a Migraine Disparities and Diagnosis Undergraduate Medical Educational Program to Underrepresented In Medicine Medical Student Members of the Student National Medical Association. American Headache Society Scientific Meeting, 2023.
- Charleston L 4th, Gupta P., Sehgal, R. Short-term Resolution of Visual Snow Symptoms with Occipital and Trigeminal Nerve Blocks in a Patient with Spontaneous Intracranial Hypotension Headache. American Headache Society Scientific Meeting, 2023.
- Robblee J., Orlova Y., Ahn A., Ali A., Birlea M., Charleston L. 4th, Singh N., Souza MNP. Real Life Approach to Outpatient Treatment of Status Migrainosus: A Survey Study. American Academy of Neurology Annual Meeting, 2023.
Presentations
- Migraine Pathophysiology Pearls and Peptides, Neurology Rehabilitation Grand Rounds, Michigan State University, September 13, 2024
- Changing the Tone: Taking Action Against Disparities in Migraine Care, American Headache Society's Scientific Meeting, San Diego, CA, June 15, 2024
- Introduction to Special Populations in Headache Medicine, American Academy of Neurology Annual Meeting, Denver, CO, April 15, 2024
- Headache Medicine Grand Rounds. AHS Resident Education in the Assessment and Care of Headhace (REACH) Program, Northwell Hofstra School of Medicine, Manhasset, NY, January 26, 2024
- Session Moderator: Headache and Stroke, Clinical Neurological Society of America Annual Meeting, Key Largo, FL, January 13, 2024
- Neuromodulation in Headache, Clinical Neurological Society of America Annual Meeting, Key Largo, FL, January 13, 2024
- Devices, Ditans, Gepants, mAbs oh My(Graine): Updates in Migraine Disease over the Last 5 Years, Clinical Neurological Society of America Annual Meeting, Key Largo, FL, January 13, 2024
- An Atypical Case in Headache Medicine, American Headache Society's Scottsdale Headache Symposium, Scottsdale, AZ, November 19, 2023
- Shedding a Light on Health Disparities Impacting Multicultural Patients with Migraine, American Headache Society's Scottsdale Headache Symposium, Scottsdale, AZ, November 17, 2023
- From Disparities In Headache Medicine to Diversity, Equity, Inclusion & Belonging in Headache Medicine Research, Neurology Rehabilitation Grand Rounds, Michigan State University, East Lansing, MI, September 22, 2023
- Addressing Inequities in Pain Management, Primary Care Education Consortium National Continuing Medical Education Program, August 30, 2023
- Expert Discussion on How Health Disparities Can Impact Migraine Care, National Medical Association Convention and Scientific Assembly, New Orleans, LA, July 31, 2023
- Migraine Care Developing and Delivering a Migraine Disparities and Diagnosis Undergraduate Medical Educational Program to Underrepresented in Medicine Medical Student Members of the Student National Medical Association, Assembly American Headache Society, Austin, TX, June 17, 2023
- Serving Underserved Populations: How Can We Take Action, Panelist, American Headache Society Scientific Meeting, Austin, TX, June 17, 2023
- What is the Best Acute Migraine Treatment to Give My Patient in 2023? Henry Ford Health's Annual Detroit Headache Symposium, Detroit, MI, June 2, 2023
- Introduction to Special Populations in Headache Medicine, American Academy of Neurology Annual Meeting, Boston, MA, April 27, 2023
- Black Headache Patients Matter in Neurology: Exploration of Race, Racism, Race-Based Headache Disparities, Clinical Neurological Society of America Annual Meeting, Jupiter, FL, January 16, 2023
Book Chapters
- Achieving Equity in Neurological Practice: Principles and Pathways, Editors: Ovbiagele B, Lewis S, Correa DJ, Thomas R, Charleston L 4th. Springer Scientific, New York, NY 2023
- Headache and Racial/Ethnic Disparities, Headache and Facial Pain Medicine, Author: Charleston L 4th. McGraw Hill, 2023.
- Neuro-Ophthalmology, Achieving Equity in Neurological Practice: Principles and Pathways, Editors: Ovbiagele B, Lewis S, Correa DJ, Thomas R, Charleston L 4th. Springer Scientific, New York, NY 2023
- Headache Medicine, Achieving Equity in Neurological Practice: Principles and Pathways, Editors: Ovbiagele B, Lewis S, Correa DJ, Thomas R, Charleston L 4th. Springer Scientific, New York, NY 2023
- Health Disparities and Headache Medicine, Wolff's Headache and Other Head Pain, 9th edition. Oxford University Press. 2022
- Barriers to Care and Advocacy, Wolff's Headache and Other Head Pain, 9th edition. Oxford University Press. 2022
Funding/Grants
- Amgen Competitive Grant in Migraine: Feasibility of a text messaging intervention to enhance self-management behaviors in patients with migraine. Charleston, L. 4th, PI 05/2022-09/2024.
- Genentech Health Equity (LOI): Addressing Migraine Care Access and Treatment Adherence to Reduce Migraine Disparities & Inequities. Charleston, L. 4th. PI 9/2024-9/2026
Research Interests
Headache and Facial Pain Treatment Interventions
Headache and Facial Pain Education
Headache Care/Neurological Disparities in Underrepresented Ethnic Groups/Cross-Cultural Sensitivity and Literacy
Health Care Policy and Advocacy
The Use of Nutraceuticals in Migraine Prevention
Peripheral Nerve Blocks and Other Interventional Procedures for Headache and Management
Clinical Interests
Headache and Facial Pain Treatment, Comprehensive Plan Development and Therapeutic Interventions.
Awards
Recipient of the 2024 American Neurological Association's Audrey S. Penn Lectureship Award, Abstract Bronze Ribbon Award, AMCP Managed Care and Specialty Pharmacy, Recipient of the 2022 American Headache Society's Seymour Solomon, MD Lecture Award, Abstract of Distinction Merit Award, American Neurological Association, 2022, Headache Medicine NeuroBytes Champion, 2021, Abstract of Distinction Merit Award, 2021 American Academy of Neurology, 2021 Virtual Meeting, Top Neurologist 2020, Nomination
Certifications
American Board of Psychiatry and Neurology, Adult Neurology, United Council of Neurological Subspecialties, Headache Medicine
Fellowships
Fellowship, Headache and Facial Pain, Jefferson Headache Center, Philadelphia, PA, 2009-10
Memberships
Member, Clinical Neurological Society of America, 2021-present, Member, National Medical Society, 2020-present, Member, American Academy of Neurology (AAN), 2018-present, Member, University of Michigan's Institute for Healthcare Policy and Innovation, 2016-present, Member, American Neurological Association, 2015-present, Member, International Headache Society, 2013-present, Member, National Headache Foundation, 2012-present, Member, American Headache Society, 2011-present