College of Osteopathic Medicine
College of Human Medicine

Larry Charleston, IV,

Larry Charleston, IV,
M.D., MSc, FAHS
Professor, Director of Headache & Facial Pain, Director of Faculty Development

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Biography
Biography: 

Dr. Larry Charleston, IV, graduated in Medicine from the Wayne State University School of Medicine in Detroit, Michigan. He then completed his internship in internal medicine at St. John Hospital and Medical Center in Detroit, Michigan and neurology residency at Baylor College of Medicine in Houston, Texas.  After residency training, he completed his Headache and Facial Pain fellowship at the Thomas Jefferson Headache Center in Philadelphia, Pennsylvania.  Dr. Charleston is certified in Adult Neurology by the American Board of Psychiatry and Neurology (ABPN) and Headache Medicine by the United Council of Neurological Subspecialties (UCNS).  He received his MS degree in Health and Health Care Research from the National Clinical Scholars Program at the University of Michigan in Ann Arbor, Michigan in 2017.  He joined the Department of Neurology at Michigan State University in March 2021.  

Awards
Awards: 
Recipient of the 2024 American Neurological Association's Audrey S. Penn Lectureship Award
Abstract Bronze Ribbon Award, AMCP Managed Care and Specialty Pharmacy
Recipient of the 2022 American Headache Society's Seymour Solomon, MD Lecture Award
Abstract of Distinction Merit Award, American Neurological Association, 2022
Headache Medicine NeuroBytes Champion, 2021
Abstract of Distinction Merit Award, 2021 American Academy of Neurology, 2021 Virtual Meeting
Top Neurologist 2020, Nomination
Publications
Selected Publications: 
Charleston L 4th. Developing and Delivering a Migraine Disparities and Diagnosis Undergraduate Medical Educational Program to Underrepresented in Medicine Medical Student Members of the Student National Medical Association: A Pilot Project. Headache 2024, pending
Charleston L 4th, Posas J. Categorizing Sports-Related Concussion Disparities by Key Domains of Social Determinants of Health. Curr Pain Headache Rep. 2024 Jan 16, PMID: 38227210
Charleston L 4th, Talon B,. Sullivan C., Kymes S., Regnier SA., Soni-Brehnbhatt S., Nahas SJ. Persistence to onabotulinumtoxinA and anti-CGRP monoclonal antibody therapy among patients with migraine: a retrospective cohort study. J Headache Pain, 2023 Aug 2:24(1):101, PMID: 37532991
Herne, MM, Charleston, L. Insight of a Headache Medicine provider in the Indian Health Services: A Personal and Professional Observation. Headache, 2023 May, 63(5):697-699. PMID: 37171379
Charleston, L 4th. Is headache equity an emergency (visit)? Learning from an emergency department utilization study. Headache, 2023 April, 63(4):459-460. PMID: 37036179
Charleston L 4th, Savage-Edwards B, Bragg SM, Baygani SK, Dennehy EB. Migraine history and response to lasmiditan across racial and ethnic groups. Curr Med Res Opin. 2022 Apr 3:1-10. doi: 10.1080/03007995.2022.2057152. Epub ahead of print. PMID: 35350937
VanderPluym JH, Charleston L 4th, Stitzer ME, Flippen CC 2nd, Armand CE, Kiarashi J. A Review of Underserved and Vulnerable Populations in Headache Medicine in the United States: Challenges and Opportunities. Curr Pain Headache Rep. 2022 Mar 26. doi: 10.1007/s11916-022-01042-w. Epub ahead of print. PMID: 35347652.
Buse DC, Winner PK, Charleston L 4th, Hirman J, Cady R, Brevig T. Early response to eptinezumab indicates high likelihood of continued response in patients with chronic migraine. J Headache Pain. 2022 Feb 21;23(1):29. doi: 10.1186/s10194-022-01387-y. PMID: 35189811; PMCID: PMC8903499
Lipton RB, Charleston L 4th, Tassorelli C, Brevig T, Hirman J, Cady R. Patient-reported outcomes, health-related quality of life, and acute medication use in patients with a ≥ 75% response to eptinezumab: subgroup pooled analysis of the PROMISE trials. J Headache Pain. 2022 Feb 7;23(1):23. doi: 10.1186/s10194-022-01386-z. PMID: 35130836; PMCID: PMC8903490
Minen M., Khanns D., Guiacocha J., Ehrlich A., Khan FA. Ashhar A., Birlea M., Singh N., Peretz A., Charleston L 4th.: The Role of Urgent Care Centers in Headache Management. BMC Health Serv Res 22, 162 (2022)
Reynolds, E; Burke, J; Evans, L; Syed, F; Liao, E; Lobo, R; Cooper, W; Charleston 4th, L; Callaghan, B.: Headache neuroimaging: a survey of current practice, barriers, and facilitators to optimal use. Headache. 2022 Jan;62(1):36-56. doi: 10.1111/head.14249. PMID: 35041218.
Halker Singh RB, Bobker SM, Roberts JL, Charleston L. 4th, Robbins MS, Pradhan A, Sprenger T, Poso-Rosich P, Orr SL, Powers SW, Houle TT, Turner DP, Gelfand AA. Advancing our commitment to our peer reviewers. Headache. 2021 Oct 13. Epub ahead of print.
Charleston L. 4th, Halker Singh RB. Virtual issue: Diversity, equity, and inclusion. Headache. 2021 Sep 23. doi: 10.1111/head.14209. Epub ahead of print. PMID: 34553770
Charleston L 4th, Ovbiagele B. Diversity in neurology leadership: Nuances and nudges. J Neurol Sci. 2021 Jul 15;426:117475. doi: 10.1016/j.jns.2021.117475. Epub 2021 May 3. PMID: 33965794.
Buse DC, Armand CE, Charleston L 4th, Reed ML, Fanning KM, Adams AM, Lipton RB. Barriers to care in episodic and chronic migraine: Results from the Chronic Migraine Epidemiology and Outcomes Study. Headache. 2021 Apr;61(4):628-641. doi: 10.1111/head.14103. Epub 2021 Apr 1. PMID: 33797078.
Begasse de Dhaem O, Kiarashi J, Armand CE, Charleston L 4th, Szperka CL, Lee YS, Rajapakse T, Seng EK, VanderPluym JH, Starling AJ. Ten Eleven things to facilitate participation of underrepresented groups in headache medicine research. Headache. 2021 Jun;61(6):951-960. doi: 10.1111/head.14124. Epub 2021 Jun 14. PMID: 34125956.
Kiarashi J, VanderPluym J, Szperka CL, Turner S, Minen M, Broner S, Ross AC, Wagstaff AE, Anto M, Marzouk M, Monteith Tj, Rosen N, Manrriquez SL, Seng E, Finkel A, Charleston L. 4th: Headache Factors Associated with, and Mitigation Strategies for Healthcare Disparities Faced by Patients with Headache Disorders. Neurology. 2021 Jun 9:10.1212/WNL.0000000000012261. doi: 10.1212/WNL.0000000000012261. Epub ahead of print. PMID: 34108270.
Charleston L 4th, Khalil S, Young WB. Carnitine Responsive Migraine Headache Syndrome: Case Report and Review of the Literature. Curr Pain Headache Rep. 2021 Mar 23;25(4):26. doi: 10.1007/s11916-021-00936-5. PMID: 33755806
Education
Education and Professional Positions: 
M.D., Wayne State University School of Medicine, 2001-2005
MS, Health and Health Care Research, National Clinical Scholars Program, University of Michigan, 2015-2017
Funding/Grants
Funding/Grants: 
Amgen Competitive Grant in Migraine: Feasibility of a text messaging intervention to enhance self-management behaviors in patients with migraine. Charleston, L. 4th, PI 05/2022-09/2024.
Genentech Health Equity (LOI): Addressing Migraine Care Access and Treatment Adherence to Reduce Migraine Disparities & Inequities. Charleston, L. 4th. PI 9/2024-9/2026
Abstracts
Selected Abstracts: 
Schwedt TJ, Pradhan AA, Oshinsky ML, Brin MF, Rosen H, Lalvani N, Charles A, Ashina M, Do TP, Burstein R, Gelfand AA, Dodick DW, Pozo-Rosich P, Lipton RB, Ailani J, Szperka C, Charleston 4th L, Digre KB, Russo AF, Buse DC, Powers S, Tassorelli C, Goadsby PJ. The Headache Research Priorities: Consensus Recommendations from the American Headache Society, the National Institute of Neurological Disorders and Stroke, and an International Multistakeholder Expert Group. American Headache Society Scientific Meeting, 2024.
Charleston L. 4th, Strom S, Albrecht, D, Cowan R. STS101 Demonstrated Long- Term Clinical Benefit in the Phase 3 Open-Label ASCEND Study. American Headache Society Scientific Meeting, 2024.
Ailani J., Charleston L. 4th, Strom S., Albrecht D. Subjects View Use of STS101 Favorably: Subject Impression Data From the Phase 3 Open- Label ASCEND Study. American Headache Society Scientific Meeting
Charleston L. 4th, Richard-Lee C. Red Ear Syndrome. A Case of a Rare Disease with Unusual Findings. American Headache Society Scientific Meeting, 2024.
Efficacy and Safety of Rimegepant for the Acute Treatment of Migraine in Black and African American Adults: Results From 3 Randomized, Placebo- Controlled Clinical Trials. Headache Cooperative of the Pacific (HCOP) Winter Meeting 2024.
Charleston L. 4th, Nahas S, Rieckmann A, Regnier SA, Fiore D, Sullivan C, Grossman S, Talon B. Migraine Prevention: A Retrospective Cohort Claims Database Study. (Accepted – Bronze Ribbon Award Recipient. AMCP Managed Care & Specialty Pharmacy, 2024
Blumenfeld A. Charleston L 4th, Summer K, O’Brien HL. Efficacy of OnabotulinumtoxinA Among Diverse Racial/Ethnic Groups: Post hoc Analysis of the Phase 4 COMPEL Trial, European Headache Federation Congress, 2023.
Charleston L. Migraine Disparities and Diagnosis Undergraduate Medical Educational Program to Underrepresented In Medicine Medical Student Members of the Student National Medical Association. American Neurological Association Meeting, 2023.
Charleston L. 4th, Talon B., Sullivan C., Anderson C., Kymes S., Regnier SA., Soni- Brehnbhatt S., Nahas SJ. Persistence to onabotulinumtoxinA and anti- CGRP monoclonal antibody therapy among patients with migraine: a retrospective cohort study. American Headache Society Scientific Meeting, 2023.
Charleston L. 4th, Starling A., Tariq N. Transnasal Evaporative Cooling Device for Migraine: A Randomized Trial, American Headache Society Scientific Meeting, 2023.
Charleston L. 4th, Armand CE, Helveston WR, Monteith TS, O'Brien HL, Croop R., Alexandra Thiry A., Morris BA, Forshaw M., Abbott CC. Rimegepant for the Acute Treatment of Migraine in Black and African American Adults: Results From 3 Randomized, Placebo- Controlled Clinical Trials. American Headache Society Scientific Meeting, 2023.
Charleston L. 4th. Developing and Delivering a Migraine Disparities and Diagnosis Undergraduate Medical Educational Program to Underrepresented In Medicine Medical Student Members of the Student National Medical Association. American Headache Society Scientific Meeting, 2023.
Charleston L 4th, Gupta P., Sehgal, R. Short-term Resolution of Visual Snow Symptoms with Occipital and Trigeminal Nerve Blocks in a Patient with Spontaneous Intracranial Hypotension Headache. American Headache Society Scientific Meeting, 2023.
Robblee J., Orlova Y., Ahn A., Ali A., Birlea M., Charleston L. 4th, Singh N., Souza MNP. Real Life Approach to Outpatient Treatment of Status Migrainosus: A Survey Study. American Academy of Neurology Annual Meeting, 2023.
Book Chapters
Book Chapters: 
Achieving Equity in Neurological Practice: Principles and Pathways, Editors: Ovbiagele B, Lewis S, Correa DJ, Thomas R, Charleston L 4th. Springer Scientific, New York, NY 2023
Headache and Racial/Ethnic Disparities, Headache and Facial Pain Medicine, Author: Charleston L 4th. McGraw Hill, 2023.
Neuro-Ophthalmology, Achieving Equity in Neurological Practice: Principles and Pathways, Editors: Ovbiagele B, Lewis S, Correa DJ, Thomas R, Charleston L 4th. Springer Scientific, New York, NY 2023
Headache Medicine, Achieving Equity in Neurological Practice: Principles and Pathways, Editors: Ovbiagele B, Lewis S, Correa DJ, Thomas R, Charleston L 4th. Springer Scientific, New York, NY 2023
Health Disparities and Headache Medicine, Wolff's Headache and Other Head Pain, 9th edition. Oxford University Press. 2022
Barriers to Care and Advocacy, Wolff's Headache and Other Head Pain, 9th edition. Oxford University Press. 2022
Resident Location
Current Resident Location: 
MSU Clinical Center
Academic Appointments
Academic Appointments: 
Assistant Clinical Professor, Michigan State University, College of Human Medicine, Grand Rapids, MI, 2011-13
Clinical Assistant Professor of Neurology, University of Michigan, Ann Arbor, MI, 2013-18
Clinical Associate Professor of Neurology, University of Michigan Ann Arbor, MI. 2018-21
Adjunct Faculty, Thomas Jefferson University, Philadelphia, PA, 2020-present
Professor of Neurology, Michigan State University College of Human Medicine, East Lansing, MI, 2021-present
Director, Headache Medicine and Facial Pain
Director, Department Faculty Development
Postdoctoral Training
Postdoctoral Training: 
Internship, Internal Medicine, St. John Hospital and Medical Center, Detroit, MI, 2005-2006
Residency, Neurology, Baylor College of Medicine, Houston, TX, 2006-2009
Fellowship, Headache and Facial Pain, Jefferson Headache Center, Philadelphia, PA, 2009-10
Clinical Interests
Clinical Interests: 

Headache and Facial Pain Treatment, Comprehensive Plan Development and Therapeutic Interventions. 

Research Interests
Research Interests: 

Headache and Facial Pain Treatment Interventions

Headache and Facial Pain Education

Headache Care/Neurological Disparities in Underrepresented Ethnic Groups/Cross-Cultural Sensitivity and Literacy

Health Care Policy and Advocacy

The Use of Nutraceuticals in Migraine Prevention

Peripheral Nerve Blocks and Other Interventional Procedures for Headache and Management

Memberships
Memberships: 
Member, Clinical Neurological Society of America, 2021-present
Member, National Medical Society, 2020-present
Member, American Academy of Neurology (AAN), 2018-present
Member, University of Michigan's Institute for Healthcare Policy and Innovation, 2016-present
Member, American Neurological Association, 2015-present
Member, International Headache Society, 2013-present
Member, National Headache Foundation, 2012-present
Member, American Headache Society, 2011-present
Fellowships
Fellowships: 
Fellowship, Headache and Facial Pain, Jefferson Headache Center, Philadelphia, PA, 2009-10
Certifications
Certifications: 
American Board of Psychiatry and Neurology, Adult Neurology
United Council of Neurological Subspecialties, Headache Medicine
Presentations
Selected Presentations: 
Migraine Pathophysiology Pearls and Peptides, Neurology Rehabilitation Grand Rounds, Michigan State University, September 13, 2024
Changing the Tone: Taking Action Against Disparities in Migraine Care, American Headache Society's Scientific Meeting, San Diego, CA, June 15, 2024
Introduction to Special Populations in Headache Medicine, American Academy of Neurology Annual Meeting, Denver, CO, April 15, 2024
Headache Medicine Grand Rounds. AHS Resident Education in the Assessment and Care of Headhace (REACH) Program, Northwell Hofstra School of Medicine, Manhasset, NY, January 26, 2024
Session Moderator: Headache and Stroke, Clinical Neurological Society of America Annual Meeting, Key Largo, FL, January 13, 2024
Neuromodulation in Headache, Clinical Neurological Society of America Annual Meeting, Key Largo, FL, January 13, 2024
Devices, Ditans, Gepants, mAbs oh My(Graine): Updates in Migraine Disease over the Last 5 Years, Clinical Neurological Society of America Annual Meeting, Key Largo, FL, January 13, 2024
An Atypical Case in Headache Medicine, American Headache Society's Scottsdale Headache Symposium, Scottsdale, AZ, November 19, 2023
Shedding a Light on Health Disparities Impacting Multicultural Patients with Migraine, American Headache Society's Scottsdale Headache Symposium, Scottsdale, AZ, November 17, 2023
From Disparities In Headache Medicine to Diversity, Equity, Inclusion & Belonging in Headache Medicine Research, Neurology Rehabilitation Grand Rounds, Michigan State University, East Lansing, MI, September 22, 2023
Addressing Inequities in Pain Management, Primary Care Education Consortium National Continuing Medical Education Program, August 30, 2023
Expert Discussion on How Health Disparities Can Impact Migraine Care, National Medical Association Convention and Scientific Assembly, New Orleans, LA, July 31, 2023
Migraine Care Developing and Delivering a Migraine Disparities and Diagnosis Undergraduate Medical Educational Program to Underrepresented in Medicine Medical Student Members of the Student National Medical Association, Assembly American Headache Society, Austin, TX, June 17, 2023
Serving Underserved Populations: How Can We Take Action, Panelist, American Headache Society Scientific Meeting, Austin, TX, June 17, 2023
What is the Best Acute Migraine Treatment to Give My Patient in 2023? Henry Ford Health's Annual Detroit Headache Symposium, Detroit, MI, June 2, 2023
Introduction to Special Populations in Headache Medicine, American Academy of Neurology Annual Meeting, Boston, MA, April 27, 2023
Black Headache Patients Matter in Neurology: Exploration of Race, Racism, Race-Based Headache Disparities, Clinical Neurological Society of America Annual Meeting, Jupiter, FL, January 16, 2023
Subspecialty
Subspecialty: 
Headache and Facial Pain

Contact Info.

MSU Clinical Center
804 Service Road
Room: A-217
East Lansing
MI
48824
Office Phone: 517-432-9277
Clinic Phone: 517-353-8122
Charles6@msu.edu

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Academic Fax: (517) 432-9414
E-Mail: msuneurology@ht.msu.edu
Michigan State University
Department of Neurology and Ophthalmology
Clinical Center
804 Service Road, Room A-217
East Lansing, MI 48824

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