College of Osteopathic Medicine
College of Human Medicine

Larry Charleston, IV,

Larry Charleston, IV,
M.D., MSc, FAHS
Professor, Director of Headache & Facial Pain, Director of Faculty Development

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Biography
Biography: 

Dr. Larry Charleston, IV, graduated in Medicine from the Wayne State University School of Medicine in Detroit, Michigan. He then completed his internship in internal medicine at St. John Hospital and Medical Center in Detroit, Michigan and neurology residency at Baylor College of Medicine in Houston, Texas.  After residency training, he completed his Headache and Facial Pain fellowship at the Thomas Jefferson Headache Center in Philadelphia, Pennsylvania.  Dr. Charleston is certified in Adult Neurology by the American Board of Psychiatry and Neurology (ABPN) and Headache Medicine by the United Council of Neurological Subspecialties (UCNS).  He received his MS degree in Health and Health Care Research from the National Clinical Scholars Program at the University of Michigan in Ann Arbor, Michigan in 2017.  He joined the Department of Neurology at Michigan State University in March 2021.  

Awards
Awards: 
Recipient of the 2022 American Headache Society's Seymour Solomon, MD Lecture Award
Selected American Academy of Neurology 2021 Headache Medicine NeuroBytes Champion, 2020-present
Abstract of Distinction Merit Award, 2021 American Academy of Neurology, 2021 Virtual Meeting
Top Neurologist 2020, Nomination
Publications
Selected Publications: 
Charleston L 4th, Savage-Edwards B, Bragg SM, Baygani SK, Dennehy EB. Migraine history and response to lasmiditan across racial and ethnic groups. Curr Med Res Opin. 2022 Apr 3:1-10. doi: 10.1080/03007995.2022.2057152. Epub ahead of print. PMID: 35350937
VanderPluym JH, Charleston L 4th, Stitzer ME, Flippen CC 2nd, Armand CE, Kiarashi J. A Review of Underserved and Vulnerable Populations in Headache Medicine in the United States: Challenges and Opportunities. Curr Pain Headache Rep. 2022 Mar 26. doi: 10.1007/s11916-022-01042-w. Epub ahead of print. PMID: 35347652.
Buse DC, Winner PK, Charleston L 4th, Hirman J, Cady R, Brevig T. Early response to eptinezumab indicates high likelihood of continued response in patients with chronic migraine. J Headache Pain. 2022 Feb 21;23(1):29. doi: 10.1186/s10194-022-01387-y. PMID: 35189811; PMCID: PMC8903499
Lipton RB, Charleston L 4th, Tassorelli C, Brevig T, Hirman J, Cady R. Patient-reported outcomes, health-related quality of life, and acute medication use in patients with a ≥ 75% response to eptinezumab: subgroup pooled analysis of the PROMISE trials. J Headache Pain. 2022 Feb 7;23(1):23. doi: 10.1186/s10194-022-01386-z. PMID: 35130836; PMCID: PMC8903490
Minen M., Khanns D., Guiacocha J., Ehrlich A., Khan FA. Ashhar A., Birlea M., Singh N., Peretz A., Charleston L 4th.: The Role of Urgent Care Centers in Headache Management. BMC Health Serv Res 22, 162 (2022)
Reynolds, E; Burke, J; Evans, L; Syed, F; Liao, E; Lobo, R; Cooper, W; Charleston 4th, L; Callaghan, B.: Headache neuroimaging: a survey of current practice, barriers, and facilitators to optimal use. Headache. 2022 Jan;62(1):36-56. doi: 10.1111/head.14249. PMID: 35041218.
Halker Singh RB, Bobker SM, Roberts JL, Charleston L. 4th, Robbins MS, Pradhan A, Sprenger T, Poso-Rosich P, Orr SL, Powers SW, Houle TT, Turner DP, Gelfand AA. Advancing our commitment to our peer reviewers. Headache. 2021 Oct 13. Epub ahead of print.
Charleston L. 4th, Halker Singh RB. Virtual issue: Diversity, equity, and inclusion. Headache. 2021 Sep 23. doi: 10.1111/head.14209. Epub ahead of print. PMID: 34553770
Charleston L 4th, Ovbiagele B. Diversity in neurology leadership: Nuances and nudges. J Neurol Sci. 2021 Jul 15;426:117475. doi: 10.1016/j.jns.2021.117475. Epub 2021 May 3. PMID: 33965794.
Buse DC, Armand CE, Charleston L 4th, Reed ML, Fanning KM, Adams AM, Lipton RB. Barriers to care in episodic and chronic migraine: Results from the Chronic Migraine Epidemiology and Outcomes Study. Headache. 2021 Apr;61(4):628-641. doi: 10.1111/head.14103. Epub 2021 Apr 1. PMID: 33797078.
Begasse de Dhaem O, Kiarashi J, Armand CE, Charleston L 4th, Szperka CL, Lee YS, Rajapakse T, Seng EK, VanderPluym JH, Starling AJ. Ten Eleven things to facilitate participation of underrepresented groups in headache medicine research. Headache. 2021 Jun;61(6):951-960. doi: 10.1111/head.14124. Epub 2021 Jun 14. PMID: 34125956.
Kiarashi J, VanderPluym J, Szperka CL, Turner S, Minen M, Broner S, Ross AC, Wagstaff AE, Anto M, Marzouk M, Monteith Tj, Rosen N, Manrriquez SL, Seng E, Finkel A, Charleston L. 4th: Headache Factors Associated with, and Mitigation Strategies for Healthcare Disparities Faced by Patients with Headache Disorders. Neurology. 2021 Jun 9:10.1212/WNL.0000000000012261. doi: 10.1212/WNL.0000000000012261. Epub ahead of print. PMID: 34108270.
Charleston L 4th, Khalil S, Young WB. Carnitine Responsive Migraine Headache Syndrome: Case Report and Review of the Literature. Curr Pain Headache Rep. 2021 Mar 23;25(4):26. doi: 10.1007/s11916-021-00936-5. PMID: 33755806
Charleston L. 4th: Headache Disparities in African Americans: A narrative review and response to the National Institute of Neurological Disorders and Stroke Request for information on Neurological Disparities in the United States Journal of the National Medical Association. (In Press) PMID: 33160641
Charleston L. 4th, Spears, RC: Equity of African-American Men in Headache in the United States: a perspective from African American Headache Medicine Specialists. Part 2 Headache: The Journal of Head & Face Pain 0: 1-9, 2020. PMID: 33141447
Charleston L. 4th, Spears RC, Flippen CC.: Equity of African-American Men in Headache in the United States: a perspective from African American Headache Medicine Specialists. Part 1 Headache: The Journal of Head & Face Pain 0: 1-13, 2020. PMID: 33140448
Charleston L. 4th, Cooper, W: An Update on Idiopathic Hypertrophic Cranial Pachymeningitis for the Headache Practitioner Current Headache and Pain Reports 24 (10): 57, 2020. 32803475
Charleston, L. 4th: Cross-Cultural Headache Care Within the United States: Speaking the Unspoken Language Headache the Journal of Head and Face Pain 0: 1-5, 2020. PM32535945
Education
Education and Professional Positions: 
M.D., Wayne State University School of Medicine, 2001-2005
MS, Health and Health Care Research, National Clinical Scholars Program, University of Michigan, 2015-2017
Funding/Grants
Funding/Grants: 
Diversity in Headache Advisory Council (DiHAC) Grant: Identifying and strengthening headache literacy knowledge domain of migraine diagnosis and disparities in underrepresented in medicine medical students and communities; Diversity in Headache Advisory Council (DiHAC) Grant, 2/2021-07/2022
Amgen Competitive Grant in Migraine: Feasibility of a text messaging intervention to enhance self-management behaviors in patients with migraine. Charleston, L. 4th, PI 05/2022-11/2023.
Abstracts
Selected Abstracts: 
Charleston L 4th, Cohen JM, Ning X, Campos VR, Rarash S. Lengil T, Kim B. Safety and Efficacy of Fremanezumab in Different Racial and Ethnic Subgroups of Patients With Migraine: A Pooled Analysis of Phase 3 Studies. 2022 American Academy of Neurology Annual Meeting, 2022
Lipton RB, Charleston L 4th, Tassorelli C, Brevig T, Hirman J, Cady R.: Patients with Migraine Who Achieved a ≥75% Reduction in Monthly Migraine Days with Eptinezumab Treatment: Subgroup Analysis of PROMISE-1 and PROMISE-2. 2022 Diamond Headache Winter Conference
Charleston L 4th, Campos VR, Ning X, Krasenbaum L, Janka L, Kessler Y, Nahas S. Six-month Safety and Efficacy of Fremanezumab in Migraine: Pooled Analysis from Phase 3 FOCUS and HALO Trials. 2022 American Academy of Neurology Annual Meeting, 2022
Charleston L 4th, Cohen JM, Ning X, Campos VR, Rarash S. Lengil T, Kim B. Pooled Analysis of Safety and Efficacy of Fremanezumab in Different Racial and Ethnic Subgroups of Patients With Migraine. 2021 International Headache Congress Meeting, 2021
Lipton RB, Charleston L 4th, Tassorelli C, Brevig T, Hirman J, Cady R.: Patients with Migraine Who Achieved a ≥75% Reduction in Monthly Migraine Days with Eptinezumab Treatment: Subgroup Analysis of PROMISE-1 and PROMISE-2, 2021 International Headache Congress Meeting, 2021
Underrepresented in Medicine: Identifying Representation in Neurology Subspecialty Society Recognition Awards. Anne Koronkiewicz, DO1* Alexandra Below, DO1* Alain Lekoubou, MD MS2 Bruce Ovbiagele, MD, MSc, MAS, MBA, FRCP3 Larry Charleston IV, MD, MSc, FAHS1 1 Department of Neurology, Michigan State University College of Human Medicine, East Lansing, Michigan 2 Department of Neurology, Penn State University, Hershey Medical Center, Hershey, Pennsylvania 3 Department of Neurology, University of California, San Francisco, California *Anne Koronkiewicz, DO and Alexandra Below, DO are joint first authors. American Neurological Association 2021 Meeting (Accepted)
DEARTH OF RECOGNITION AWARDS GIVEN TO UNDERREPRESENTED IN MEDICINE INDIVIDUALS BY MAJOR US NEUROLOGICAL SOCIETIES Omolara Lawal1 * Abena Kwegyir-Aggrey1* Larry Charleston IV2 Bruce Ovbiagele3 Alain Lekoubou1 Department of Neurology, Penn State University, Hershey Medical Center, Hershey, Pennsylvania2 Department of Neurology, Michigan State University College of Human Medicine, East Lansing, Michigan 3 Department of Neurology, University of California, San Francisco * Omolara Lawal and Abena Kwegyr-Aggrey are joint first authors. American Neurological Association 2021 Meeting (Accepted)
Charleston L 4th: Identifying and Understanding Microaggressions among Michigan Medicine African- American Faculty Members, AAN Annual Meeting, 2021.
Minen MT, Ehrlick A, Khanns D, Guiracocha JS, Khan F, Ali A, Birlea M, Singh N, Peretz A, Charleston L 4th: What Role do Urgent Care Centers Play in Headache Management? A Quality Improvement Study of Select Urgent Care Facilities, 2021 AHS Annual Scientific Meeting, 2021.
Lipton RB, Charleston L 4th, Tassorelli C, Brevig T, Hirman J, Cady R.: Patients with Migraine Who Achieved a ≥75% Reduction in Monthly Migraine Days with Eptinezumab Treatment: Subgroup Analysis of PROMISE-1 and PROMISE-2, 2021 AHS Annual Scientific Meeting, 2021.
Buse DC, Winner PK, Charleston L 4th, Hirman J, Cady R, Brevig T.: Early Response to Eptinezumab Indicates High Likelihood of Continued Response with Treatment in Patients with Chronic Migraine, 2021 AHS Annual Scientific Meeting, 2021.
Resident Location
Current Resident Location: 
MSU Clinical Center
Academic Appointments
Academic Appointments: 
Assistant Clinical Professor, Michigan State University, College of Human Medicine, Grand Rapids, MI, 2011-13
Clinical Assistant Professor of Neurology, University of Michigan, Ann Arbor, MI, 2013-18
Clinical Associate Professor of Neurology, University of Michigan Ann Arbor, MI. 2018-21
Adjunct Faculty, Thomas Jefferson University, Philadelphia, PA, 2020-present
Professor of Neurology, Michigan State University College of Human Medicine, East Lansing, MI, 2021-present
Director, Headache Medicine and Facial Pain
Director, Department Faculty Development
Postdoctoral Training
Postdoctoral Training: 
Internship, Internal Medicine, St. John Hospital and Medical Center, Detroit, MI, 2005-2006
Residency, Neurology, Baylor College of Medicine, Houston, TX, 2006-2009
Fellowship, Headache and Facial Pain, Jefferson Headache Center, Philadelphia, PA, 2009-10
Clinical Interests
Clinical Interests: 

Headache and Facial Pain Treatment, Comprehensive Plan Development and Therapeutic Interventions. 

Research Interests
Research Interests: 

Headache and Facial Pain Treatment Interventions

Headache and Facial Pain Education

Headache Care/Neurological Disparities in Underrepresented Ethnic Groups/Cross-Cultural Sensitivity and Literacy

Health Care Policy and Advocacy

The Use of Nutraceuticals in Migraine Prevention

Peripheral Nerve Blocks and Other Interventional Procedures for Headache and Management

Memberships
Memberships: 
Member, Clinical Neurological Society of America, 2021-present
Member, National Medical Society, 2020-present
Member, American Academy of Neurology (AAN), 2018-present
Member, University of Michigan's Institute for Healthcare Policy and Innovation, 2016-present
Member, American Neurological Association, 2015-present
Member, International Headache Society, 2013-present
Member, National Headache Foundation, 2012-present
Member, American Headache Society, 2011-present
Fellowships
Fellowships: 
Fellowship, Headache and Facial Pain, Jefferson Headache Center, Philadelphia, PA, 2009-10
Certifications
Certifications: 
American Board of Psychiatry and Neurology, Adult Neurology
United Council of Neurological Subspecialties, Headache Medicine
Presentations
Selected Presentations: 
Advance Headache Diagnosis and Management Intensive Sessions: Live Case-Based Simulations, Procedures, Neuromodulation, and Mentoring. Thomas Jefferson University, Philadelphia, PA. June 25-26, 2022
Black Headache Patients Matter: Exploration of Race, Racism, Race-Based Headache Disparities, and Professional Ethics- 2022 Seymour Solomon Award Lecture. 2022 AHS 64th Annual Scientific Meeting, Aurora, CO. June 10, 2022
Healthcare Disparities of Migraine Disease in the African American Population. Society of Black Neurologists and AbbVie Neuroscience Roundtable Discussion. Co-moderator and Program Development Committee. (Held in conjunction with the American Academy Neurology 74th Annual Meeting). Seattle, WA. April 4, 2022
Strategies for Personal Leadership: Developing the Leader Within. Proposal, Curriculum Developer and Program lead. American Academy of Neurology 74th Annual Meeting. Seattle, WA. April 4, 2022
Disparities in Headache Care in the United States. Headache Cooperative of New England 32nd Stowe Headache Symposium. April 2, 2022.
Michigan State University College of Osteopathic Medicine Summer Symposium: Toward Achieving Diversity, Equity and Inclusion in Headache Medicine: Migraine Diagnosis and A Perspective on African-American Disparities in Migraine, Traverse City, MI. June 24, 2022
Michigan State University College of Human Medicine, Diversity Equity & Inclusion Grand Rounds: Toward Achieving Diversity, Equity and Inclusion in Headache Medicine: A Perspective on African-American Disparities in Migraine, Virtual Presentation, October 12, 2021
Healthcare Disparities Put "Undue" Disease Burden on Patients; Contributors: Hope L. O'Brien, MD and Larry Charleston, IV, MD; Video Commentary, Medscape, November 19, 2021.
Disparities in Headache and Migraine Care: Access Concerns, Alliance for Patient Access Headache and Migraine Workgroup Meeting, November 2020, Virtual
Candid Conversation: Why Research Matters? bias, Beliefs and Myths. A candid discussion on headache care disparities and clinical research participation of underrepresented ethnic groups, Delta Research and Educational Foundation (DREF), November 2020, Virtual
Embracing New Treatment Options in the Management of Migraine Headache, Continuing Education Alliance (CEA) and Practicing Clinicians Exchange (PCE), May 2020, Virtual
Migraine Expert Advisor/Stakeholder Panel Member, PCORI Project: Non-pharmacological Modalities for Migraine Prevention Mapping Project, ECRI Institute Evidence Practice-Based Practice Center for Clinical Excellence and Guidelines, April 2021, US
Subspecialty
Subspecialty: 
Headache and Facial Pain

Contact Info.

MSU Clinical Center
804 Service Road
Room: A-217
East Lansing
MI
48824
Office Phone: 517-432-9277
Clinic Phone: 517-353-8122
Charles6@msu.edu

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Academic Fax: (517) 432-9414
E-Mail: msuneurology@ht.msu.edu
Michigan State University
Department of Neurology and Ophthalmology
Clinical Center
804 Service Road, Room A-217
East Lansing, MI 48824

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