Andrea Bozoki

Dr. Bozoki graduated in 1993 from the State University of New York, Health Sciences Center at Brooklyn. She did an internship at Beth Israel Medical Center in Manhattan and then moved to the Midwest to pursue a residency in Neurology at the University of Michigan. She went on to do a 2 year clinical fellowship in Geriatric Neurology and then joined the Institute of Gerontology in order to obtain an additional 2 years of research training in memory disorders of aging and early Alzheimer’s disease, all at the University of Michigan. She was board-certified in 1998, and joined the faculty as an assistant professor in the Department of Neurology and Neuro-ophthalmology at Michigan State University in 2001 with admitting privileges at both Ingham Regional Medical Center and Sparrow Hospital.

Since joining the faculty of MSU in July 2001, she divides her time between clinical care of patients (specializing in neurologic dysfunctions of those over age 60) and research examining the effects of aging and dementia on memory networks of the brain using functional magnetic resonance imaging.

Academic Appointments

2016-Present: Professor, Michigan State University, Neurology, 2009-Present: Director, Geriatric and Cognitive Neurology, Michigan State University, Neurology, 2010-2016: Associate Professor, Michigan State University, Neurology, 2001-2010: Assistant Professor, Michigan State University, Neurology

Education

  • M.D., SUNY Health Sciences Center at Brooklyn, School of Medicine; New York City, NY 1993
  • B.S., Biology, Cornell University, College of Agriculture and Life Sciences; Ithaca, NY 1986

Postdoctoral Training

Research Fellowship, Institute of Gerontology, University of Michigan; Ann Arbor, MI 2001, Geriatric Neurology Fellowship, University of Michigan Department of Neurology; Ann Arbor, MI 1999, Neurology Residency, University of Michigan Medical Center; Ann Arbor, MI 1997, Internal Medicine Internship, Beth Israel Medical Center; New York City, NY

Publications

  • Beach PA, Huck JT, Miranda M, Bozoki AC, Autonomic, behavioral, and subjective pain responses in Alzheimer’s disease, Pain Medicine, 2015, in press.
  • Korolev IO, Zhu DC, Symonds L, Bozoki AC, Predicting Progression from Mild Cognitive Impairment to Alzheimer's Dementia using Clinical, MRI, and Plasma Biomarkers via Probabilistic Pattern Classification. PLOS One, 2015, in press.
  • Curtis C, Garnet JE, Singh U, et al. Phase 3 Trial of Flutemetamol Labeled With Radioactive Fluorine 18 Imaging and Neuritic Plaque Density. JAMA Neurol. 2015 Jan 26 [epub ahead of print]
  • Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, et al, Bapineuzumab 301 and 302 Clinical Trial Investigators. Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. N Engl J Med. 2014 Jan 23;370(4):322-33.
  • Bozoki A, Radovanovic M, Winn B, Heeter C, Anthony JC. Effects of a computer-based cognitive exercise program on age-related cognitive decline. Arch Gerontol Geriatr. 2013 Jul-Aug;57(1):1-7.
  • Zhu DC, Majumdar S, Korolev IO, Berger KL, Bozoki AC. Alzheimer’s disease and amnestic Mild Cognitive Impairment weaken connections within the Default Mode Network: a multimodal imaging study. Journal of Alzheimer’s Disease; 2013 Jan 1:34(4):969-84
  • Carmichael O, Xie J, Fletcher E, Singh B, DeCarli C; Alzheimer's Disease Neuroimaging Initiative. Localized hippocampus measures are associated with Alzheimer pathology and cognition independent of total hippocampal volume. Neurobiol Aging. 2012 Jun;33(6):1124.e31-41.
  • Bozoki AC, Korolev IO, Davis NC, Hoisington LA, Berger KL. Disruption of Limbic White Matter Pathways in Mild Cognitive Impairment and Alzheimer’s Disease: a DTI/FDG-PET Study. Human Brain Mapping, Jun 2011; doi: 10.1002/hbm.21320
  • Huang J, Zong X, Arnold Wilkins A, Jenkins B, Bozoki A, Cao Y. fMRI evidence that precision ophthalmic tints reduce cortical hyperactivation in migraine. Cephalgia. Jun 2011; 31(8):925-362011
  • Kim SY, Karlawish JH, Kim HM, Wall IF, Bozoki AC, Appelbaum PS. Preservation of the capacity to appoint a proxy decision maker: implications for dementia research. Arch Gen Psychiatry. 2011 Feb;68(2):214-20.
  • Bozoki A, An H, Bozoki ES, Little R. The Existence of Cognitive Plateaus in Alzheimer Disease. Alzheimer’s & Dementia, 2009; 5(6):470-478
  • An H, Little R, Bozoki A. A Statistical Algorithm for Detecting Cognitive Plateaus in Alzheimer's Disease. Journal of Applied Statistics, 2010; 37(5):779-789
  • Bozoki A, Farooq MU. Frontotemporal Dementia: insights from neuropsychology and neuroimaging. International Review of Neurobiology, 2009; 84:185-213

Abstracts

  • Hannah A, Alsibai A, Bozoki AC. The effect of obesity on severity of cognitive impairment and neuropsychiatric symptoms in MCI. AAN 67th Annual Meeting, Washington DC, April 18-25, 2015
  • Bozoki AC, Gentchev M, Zhu DC. Effects of Asymptomatic B-amyloid Positivity on Regional Cerebral Metabolism and CSF-pTau Levels. 9th Human Amyloid Imaging Conference, Miami, January 14-16, 2015.
  • Beach P, Huck J, Zhu DC and Bozoki AC. Resting-state Neural Correlates of Increased Acute Pain Sensitivity in Alzheimer’s Disease. Michigan Osteopathic Association Annual Scientific Convention, Detroit, May 14-17, 2014.
  • Hannah A, Todem D and Bozoki AC. Mild Cognitive Impairment: Neuropsychiatric Symptom Prevalence by BMI and within Cognitive Subtypes. AAN 66th Annual Meeting, Philadelphia, April 26-May 3 2014.
  • Beach P, Huck J, Miranda M, Swanic K, Symonds L, Zhu D and Bozoki AC. Effects of Alzhiemer’s disease progression on acute pain behaviors. Society for Neuroscience Annual Meeting, San Diego, November 9-13, 2013.
  • Beach, P., Miranda, M., Swanic, K., Symonds, L., Zhu, D., Bozoki, A. Effects of severe Alzheimer’s disease on acute pain behaviors and resting-state functional connectivity among pain processing brain regions. American Physician Scientists Association 9th Annual Meeting. Chicago, IL. 2013
  • Beach P, Symonds L, Zhu DC, Foley K, Bozoki AC. How are pain behaviors and pain processing altered in severe Alzheimer's disease? Society for Neuroscience Annual Meeting, New Orleans, LO, October 13-17 2012
  • Beach P, Foley K, Symonds L, Bozoki AC. Pain Responses in Severe Alzheimer’s disease. Alzheimer’s Association International Conference, Vancouver, B.C. Canada, July 14-19 2012
  • Hannah A, Symonds L, and Bozoki AC. Mild Cognitive Impairment: Neuropsychiatric symptom effects on disease progression. Alzheimer’s Association International Conference, Vancouver, B.C. Canada, July 14-19 2012

Book Chapters

  • Bozoki A, Giordani B, Heidebrink JL, Berent S, Foster NL. Synopsis of: Mild Cognitive Impairments Predict Dementia in Non-demented Elderly with Memory Loss, in Research and Practice in Alzheimer’s Disease. Serdi 2002 Vol. 6: 33-37
  • Foster NL, Bozoki A, Minoshima S, Kuhl DE, Giordani B, Berent S: Isolated Memory Impairment: Clues from Imaging and Follow-up Studies, in The Shadow Line from Normal Aging to Dementia, Brecia: IRCCS San Giovanni di Dio FBF 2002

Research Interests

My lab is currently focused on studying the memory deficits that occur during the transition from normal aging to Alzheimer's disease (AD). We are studying 3 groups of individuals; healthy seniors, those with Mild Cognitive Impairment (a diagnosis that encompasses both memory-predominant and other-cognitive predominant deficits that are not severe enough to be considered dementia) and those with early stage AD. We are using event-related fMRI to visualize neural network differences between successful and unsuccessful learning attempts, both within and across groups. An offshoot of this work is a study examining the differences between rapid presentation of to-be-remembered stimuli (every 2.5 - 7.5 sec) versus traditional event-related presentation timing (every 15 sec). This latter study is being performed in a population of young (college-age) subjects.

The second focus of the lab is the use of a method known as DTI, which allows for evaluation of the integrity of white matter tracts. It has been established that fractional anisotropy (a measure of water diffusion along a vector) is decreased during aging in several major pathways (ie corpus callosum). It is the intention of this work to delineate whether the fornix (the main outflow pathway from the hippocampal complex) shows similar changes during aging, and could be used as a marker early in the process of converting to AD.

Please feel free to contact me if you have any questions about my research: andrea.bozoki@hc.msu.edu

Fellowships

Fellow, American Academy of Neurology 2015, Fellow, American Neurological Association 2014

Memberships

American Academy of Neurology, Michigan Neurological Association, Society for Behavioral and Cognitive Neurology, Geriatric Neurology section of the AAN, Cognitive Neuroscience Society, Behavioral Neurology section of the AAN, American Neurological Association

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