Karl Seydel, M.D., Ph.D.
Assistant Professor
Michigan State University
Department of Internal Medicine
College of Osteopathic Medicine
East Lansing, MI 48824

Mailing Address:
B305 West Fee Hall

Phone: 517-353-3211
Fax: 517-432-1062
Email: seydel@msu.edu

Karl Seydel, M.D., Ph.D., earned medical and doctorate degrees from Washington University in St. Louis, Missouri in 1999, where he participated in their Medical Scientist Training Program.  Dr. Seydel recently joined the faculty of Michigan State University’s Department of Internal Medicine after working for six years as a fellow at the National Institute of Health’s Laboratory of Malaria and Vector Research.  Dr. Seydel holds M.S. and B.S. degrees in Biological Sciences from Stanford University.  

Dr. Seydel is interested in the clinical heterogeneity of malarial disease. While some children present with life threatening symptoms with a relatively low parasite burden, others are completely asymptomatic with a large parasite burden. He is investigating whether differences in the levels of cytoadherence of parasitized erythrocytes to endothelial cells of the microvasculature can account for these differences in disease severity. Dr. Seydel splits his time between a laboratory in Blantyre, Malawi and one at Michigan State University.

Relevant Publications

1.      Shizuru, J.A. , Seydel, K.B. , Flavin, T.F. , Wu, A.P. , Kong, C.C. , Hoyt, E.G. , Fujimoto, N. , Billingham, M.E.,  Starnes, V.A. , and Fathman, C.G. 1990. Induction of donor-specific unresponsiveness to cardiac allografts in rats by pretransplant anti-CD4 monoclonal antibody therapy.  Transplantation. 50: 366-73.

2.      Flavin, T. , Shizuru, J. , Seydel, K. , Wu, A. , Fujimoto, N. , Hoyt, E.G. , Ivens, K. , Billingham, M. , Fathman, C.G. ,and Starnes, V.A. 1990.  Selective T-cell depletion with Ox-38 anti-CD4 monoclonal antibody prevents cardiac allograft rejection in rats. J. Heart Trans. 9:482-8.

3.      Seydel, K. , Shizuru, J. , Grossman, D. , Wu, A. , Alters, S. , and Fathman, C.G. 1991. Anti-CD8 abrogates effect of anti-CD4-mediated islet allograft survival in rat model. Diabetes. 40:1430-4.

4.      Alters, S. , Shizuru, J.A. , Ackerman, J. , Grossman, D. , Seydel, K.B. , and Fathman, C.G. 1991. Anti-CD4 mediates clonal anergy during transplantation tolerance induction. J. Exp. Med. 173:491-4.

5.      Seydel, K.B. , Braun, K.L. , Zhang, T. , Jackson, T. F. , and Stanley, S.L. Jr. 1996. Protection against amebic liver abscess formation in the severe combined immunodeficient mouse by human anti-amebic antibodies. Am. J. Trop. Med. & Hyg. 55: 330-2.

6.      Seydel, K.B. , Li, E. , Swanson, P.E. , and Stanley, S.L. Jr. 1997. Human intestinal epithelial cells produce proinflammatory cytokines in response to infection in a SCID mouse-human intestinal xenograft model of amebiasis. 1997. Infect. Immun. 65:1631-9.

7.      Lotter, H. , Zhang, T. , Seydel, K.B., Stanley, S.L. Jr. , and Tannich, E. 1997. Identification of an epitope on the  Entamoeba  histolytica 170-kD lectin conferring antibody-mediated protection against invasive amebiasis. J. Exp. Med. 185:1793-801.

8.      Seydel, K.B. , Zhang, T. , and Stanley, S.L. Jr. 1997. Neutrophils play a critical role in early resistance to amebic liver abscesses in severe combined immunodeficient mice. Infect. Immun. 65:3951-3.

9.      Seydel, K.B. Li, E., Zhang, Z., and Stanley, S.L. Jr. 1998. Epithelial cell-initiated inflammation plays a crucial role in early tissue damage in amebic infection of human intestines. Gastroenterology. 115:1446-53.

10.    Seydel K.B. and Stanley, S.L. Jr. 1998. Entamoeba histolytica induces host cell death in amebic liver abscess by a non-Fas-dependent, non-tumor necrosis factor alpha-dependent pathway of apoptosis. Infect. Immun 66:2980-3.

11.    Seydel, K.B.. Zhang, T. Champion, G.A., Fichtenbaum, C., Swanson, P.E., Tzipori, S., Griffiths, J.K., Stanley, S.L., Jr. 1998.  Cryptosporidium parvum infection of human intestinal xenografts in SCID mice induces production of human tumor necrosis factor alpha and interleukin-8. Infect. Immun. 66:2379-82.

12.    Seydel, K.B., Smith ,S. J., and Stanley, S.L.Jr. 2000. Interferon-gamma and nitric oxide are required for host defense in murine model of amebic liver abscess. Infect. Immun. 68:400-2.

13.    Zhang Z, Wang, L. , Seydel, K.B., Li, E., Ankri S., Mirelman, D. and Stanley, S.L. Jr. 2000. Entamoeba histolytica cysteine proteinases with interleukin-1 beta converting enzyme (ICE) activity cause intestinal inflammation and tissue damage in amoebiasis. Mol. Microbiol. 37:542-8.

14.    Zhang, Z. , Jin, L. , Champion, G. , Seydel, K.B.  and Stanley, S.L. Jr. 2001. Shigella infection in a scid mouse-human intestinal xenograft model: role for neutrophils in containing bacterial dissemination in human intestine. Infect. Immun. 69:3240-7.

15.    Samaan, R., Nemes, A., Pearce, K., Matheny, S., Crockett, S., Seydel, K.  (2001) Ambulatory Diagnoses-Cluster Statistics of Patient Visits at a Clinic in the Amazon Region of Ecuador. Rural and Remote Health 1, http://rrh.deakin.edu.au

16.    Nagao, E., Seydel, K.B. and Dvorak, J.A. 2002. Detergent-resistant erythrocyte membrane rafts are modified by a Plasmodium falciparum infection. Exp. Parsitol. 102:57-9.

17.    Sijwali, P.S., Kato, K., Seydel, K.B., Gut, J., Lehman, J., Klemba, M., Goldberg, D.E., Miller, L.H. and Rosenthal, P.J. 2004. Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites. PNAS. 101:8721-6.

18.    Seydel, K.B., Gaur, D., Aravind, L., Subramanian, G., and Miller, L.H. 2005. Plasmodium falciparum: characterization of a late asexual stage Golgi protein containing both ankyrin and DHHC domains. Exp. Parasitol. 110:389-93.

19.    Seydel, K.B., Milner, D.A. Jr., Kamiza, S.B., Molyneux, M.E., and Taylor, T.E. 2006. The distribution and intensity of parasite sequestration in comatose Malawian children. Journal of Infectious Diseases. 194:208-215.

20.   Francischetti IM, Seydel KB, Monteiro RQ, Whitten RO, Erexson CR, Noronha AL, Ostera GR, Kamiza SB, Molyneux ME, Ward JM, Taylor TE. 2007. Plasmodium falciparum-infected erythrocytes induce tissue factor expression in endothelial cells and support the assembly of multimolecular coagulation complexes. J Thromb Haemost. 5(1):155-65.

21.    Mu J, Awadalla P, Duan J, McGee KM, Keebler J, Seydel K, McVean GA, Su XZ. 2007. Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome. Nat Genet. 39(1):126-30.

Chapters and Reviews:

1.      Seydel, K.B. and Stanley, S.L. Jr. 1996.  SCID mice and the study of parasitic disease. Clin. Micro. Rev. 9:126-34.

2.      Seydel, K.B. , Zhang, T. , and Stanley, S.L. Jr. 1997. Animal models of E. histolytica infection.  Handbook of Animal Models of Infectious Diseases.