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Faculty

Howard Chang, M.D., Ph.D.Howard Chang, M.D., Ph.D.
Associate Professor, Neurology

Academic Appointments

  • 2006 August: Associate Professor, Neurology, Michigan State University
  • 2006 June: Associate Professor, Pathology & Neurology, SUNY-Upstate Medical University
  • 2001-2006: Assistant Professor, Pathology & Neurology, SUNY-Upstate Medical University
  • 1991-1992: Associate Professor, Anatomy and Neurobiology, University of Tennessee
  • 1984-1991: Assistant Professor, Anatomy and Neurobiology, University of Tennessee

Postdoctoral Training

  • 1999-2001: Fellow, Neuropathology, Rhode Island Hospital, Brown University
  • 1996-1999: Resident, Anatomic Pathology, Massachusetts General Hospital, Harvard Medical School
  • 1981-1983: Postdoctoral Fellow - Neurophysiology, Michigan State University

Education

  • M.D., University of Tennessee, 1996
  • Ph.D., Michigan State University, Anatomy, 1981
  • A.B., Cornell, Biology, 1976

Research Interests

My previous research studies have been focused on the anatomy and physiology in brain regions involved in movement disorders and dementia (e.g., the basal ganglia and basal forebrain). However, as a neuroanatomist and a practicing neuropathologist, I have a broad interest in any studies that correlate anatomy, physiology, and pathology of the central nervous system. More recently, I have joined research teams interested in a variety of topic including mechanisms involved in obesity, and spinal cord injury and repair. Current potential collaboration studies at MSU include studies of atherosclerosis, stroke, Restless Legs Syndrome, and cerebral malaria.

Publications

  1. Habener, J.F., Chang, H.T., Potts, J.T. Jr. (1977) Enzymic processing of proparathyroid hormone by cell-free extracts of parathyroid glands. Biochem. 16:3910-3917.
  2. Chang, H.T., Wilson, C.J., Kitai, S.T. (1981) Single neostriatal efferent axons in the globus pallidus: A light and electron microscopic study. Science 213:915-918.
  3. Preston, R.J., McCrea, R.A., Chang, H.T., Kitai, S.T. (1981) Anatomy and physiology of substantia nigra and retrorubral neurons studied by extra- and intra¬cellular recording and by horseradish peroxidase labeling. Neuroscience 6:331-344.
  4. Bishop, G.A., Chang, H.T., Kitai, S.T. (1982) Morphological and physiological properties of neostriatal neurons: An intracellular horseradish peroxidase study in the rat. Neuroscience 7:179-191.
  5. Chang, H.T., Wilson, C.J., Kitai, S.T. (1982) A Golgi study of rat neostriatal neurons: Light microscopic analysis. J. Comp. Neurol. 208:107-126.
  6. Chang, H.T., Kitai, S.T. (1982) Large neostriatal neurons in the rat: An electron microscopic study of gold-toned Golgi-stained cells. Brain Res. Bull. 8:631-643.
  7. Wilson, C.J., Chang, H.T., Kitai, S.T. (1982) Origins of postsynaptic potentials evoked in identified rat neostriatal neurons by stimulation in substantia nigra. Exp. Brain Res. 45:157-167.
  8. Chang, H.T., Kita, H., Kitai, S.T. (1983) The fine structure of the rat subthalamic nucleus: An electron microscopic study. J. Comp. Neurol. 221:113-123
  9. Kita, H., Chang, H.T., Kitai, S.T. (1983) Pallidal inputs to subthalamus: intracellular analysis. Brain Res. 264:255-265.
  10. Kita, H., Chang, H.T., Kitai, S.T. (1983) The morphology of intracellularly labeled rat subthalamic neurons: a light microscopic analysis. J. Comp. Neurol. 215:245-257.
  11. Wilson, C.J., Chang, H.T., Kitai, S.T. (1983) Origins of postsynaptic potentials evoked in spiny neostriatal projection neurons by thalamic stimulation in the rat. Exp. Brain Res. 51:217-226.
  12. Wilson, C.J., Chang, H.T., Kitai, S.T. (1983) Disfacilitation and long-lasting inhibition of neostriatal neurons in the rat. Exp. Brain Res. 51:227-235.
  13. Chang, H.T., Kita, H., Kitai, S.T. (1984) The ultrastructural morphology of the subthalamic-nigral axon terminals intracellularly labeled with horseradish peroxidase. Brain Res. 299:182-185.
  14. Chang, H.T., Kitai, S.T. (1985) Projection neurons of the nucleus accumbens: An intracellular labeling study. Brain Res. 347:112-116.
  15. Chang, H.T., Kitai, S.T. (1986) Intracellular recordings from rat nucleus accumbens neurons IN VITRO. Brain Res. 366:392-396.
  16. Chang, H.T., Penny, G.R., Kitai, S.T. (1987) Enkephalinergic - cholinergic interactions in the rat globus pallidus: a pre-embedding double-labeling immunocytochemical study. Brain Res. 426:197-203.
  17. Chang, H.T. (1988) Substance P - Dopamine relationship in the rat substantia nigra: a light and electron microscopy study of double immunocytochemically labeled materials. Brain Res. 448:391-396.
  18. Chang, H.T. (1988) Dopamine - acetylcholine interaction in the striatum: A dual-labeling immunocytochemical study of tyrosine hydroxylase and choline acetyltransferase positive elements in the rat. Brain Res. Bull. 21:295-304.
  19. Chang, H.T. (1989) Noradrenergic innervation of the substantia innominata: A light and electron microscopic analysis of dopamine ß-hydroxylase (DBH) immunoreactive elements in the rat. Exp. Neurol. 104:101-112.
  20. Chang, H.T., Kuo, H. (1989) Calcitonin gene-related peptide (CGRP) in the rat substantia innominata and globus pallidus: A light and electron microscopic immunocytochemical study. Brain Res. 495:167-172
  21. Chang, H.T., Kuo, H. (1989) Adrenergic innervation of the rat substantia innominata: Co-localization of phenylethanolamine N-methyltransferase and tyrosine hydroxylase immunoreactivities within the same axons. Brain Res. 503:350-353.
  22. Wilson, C.J., Chang, H.T., Kitai, S.T. (1990) Firing patterns and synaptic potentials of identified giant aspiny interneurons in the rat neostriatum. J. Neurosci. 10:508-519.
  23. Chang, H.T., Kuo, H., Whittaker, J.A., Cooper, N.G.F. (1990) Light and electron microscopic analysis of projection neurons retrogradely labeled with Fluoro-Gold: notes on the application of antibodies to Fluoro-Gold. J. Neurosci. Methods 35:31-37.
  24. Galarraga, E., Bargas, J., Chang, H.T. (1990) Propiedades electrofisiologicas de una neurona "mediana sin espinas" del neoestriado. Rev. Biomed, 1:196-210.
  25. Chang, H.T., Kuo, H. (1991) Relationship of Calbindin D-28k and Cholinergic Neurons in the Nucleus Basalis of Meynert of the Monkey and the Rat. Brain Res. 549:141-145.
  26. Chang, H.T. (1991) Anterograde transport of Lucifer Yellow - Dextran conjugate. Brain Res. Bull. 26:813-816.
  27. Chang, H.T., Tian, Q. (1991) Vasoactive intestinal polypeptide (VIP) immunoreactive elements in the caudal ventral striatum of the rat: A light and electron microscopic study. Brain Res. Bull. 26:947-956.
  28. Chang, H.T., Kita, H. (1992) Interneurons in the rat striatum: Relationships between parvalbumin neurons and cholinergic neurons. Brain Res. 574:307-311.
  29. Kuo, H., Chang, H.T. (1992) Ventral pallido-striatal connection: A light and electron microscopic study in the rat. J. Comp. Neurol. 321:626-636.
  30. Chang, H.T. (1992) Immunoperoxidase labeling of the anterograde tracer Fluoro-Ruby (tetramethylrhodamine - dextran amine conjugate). Brain Res. Bull. 30:115-118.
  31. Baskerville, K.A., Herron, P., Chang, H.T. (1993) Topography of cholinergic afferents from the nucleus basalis of Meynert to representational areas of sensorimotor cortices in the rat. J. Comp. Neurol. 335:552-562.
  32. Granata, A.R., Chang, H.T. (1994) Relationship of calbindin D-28k with afferent neurons to the rostral ventrolateral medulla in the rat. Brain Research 645:265-277.
  33. Meredith, G.E., Chang, H.T. (1994) Synaptic relationships of enkephalinergic and cholinergic neurons in the nucleus accumbens of the rat. Brain Research 667:67-76.
  34. Chang, H.T., Tian, Q., Herron, P. (1995) GABAergic axons in the ventral forebrain of the rat: A quantitative electron microscopic study. Neuroscience 68:207-220.
  35. Mark, E.J., Patalas, E.D., Chang, H.T., Evans, R.J., Kessler, S.C. (1997) Fatal pulmonary hypertension associated with short-term use of fenfluramine and phentermine. N E J Med. 337:602-606.
  36. Herron, P., Baskerville, K.A., Chang, H.T., Doetsch, G.S. (1997) Distribution of neurons immunoreactive for parvalbumin and calbindin in the somatosensory thalamus of the raccoon. J Comp Neurol 388:120-9.
  37. Chang, H.T., Yantiss, R.K., Nielsen, P.G., McKee, G., Mark, E.J. (2000) Lipid-rich diffuse malignant mesothelioma - A Case Report. Human Path. 31:876-879.
  38. Adamec, E., Chang, H.T., Stopa, E.G., Hedreen, J.C., Vonsattel, J.P. (2001) Tau protein expression in frontotemporal dementias, Neurosci Lett 315:21-4.
  39. Sheu, M., Fauteux, G., Chang, H., Taylor, W., Stopa, E., Robinson-Bostom, L. (2002) Sinus pericranii: dermatologic considerations and literature review. J Am Acad Dermatol 46:934-41.
  40. Xu, J., Yeon, J.E., Chang, H., Tison, G., Chen, G.J., Wands, J., de la Monte, S. (2003) Ethanol impairs insulin-stimulated neuronal survival in the developing brain: role of PTEN phosphatase. J Biol Chem. 278:26929-37.
  41. Jung, S., Schelper, R.L, Visvesvara, G.S., Chang, H.T. (2004) Balamuthia mandrillaris meningoencephalitis in an immunocompetent patient: An unusual clinical course and a favorable outcome. Arch. Path. Lab. Med. 128:466–468.
  42. Chang, H.T., Cortez, S., Stopa, E., Vonsattel, J.-P., Schelper, R.L (2004) Familial Frontotemporal Dementia: A report of 3 cases of severe cerebral atrophy with rare inclusions that are negative for tau and synuclein, but positive for ubiquitin. Acta Neuropathologica 108(1): 10-6.
  43. Chandan, V.S., Chang, J., Schelper, R.S., Chang, H.T. (2004) A 58-year-old woman presents with paraplegia of three years duration. Neuropathology 24:263-65.
  44. Chandan, V.S., Schelper, R.L., Anthony Shrimpton, A., Hutchison, R.E., Chang, H.T. (2006) A 33-year-old male with multiple ring-enhancing lesions in the brain. Neuropathology 26: 94-7.
  45. Chang, H.T., Latorre, J.G.S., Seung Hahn, S., Dubowy, R., Schelper, R.L. (2006) Pediatric Cerebellar Pleomorphic Xanthoastrocytoma with Anaplastic Features: A case of long-term survival after multimodality therapy. Child’s Nervous System 22(6):609-13.
  46. Quintero, M., Mirza, N., Chang, H., Perl, A. (2006) Antiphospholipid antibody syndrome associated with. Primary angiitis of the central nervous system: report of two biopsy-proven cases. Annals Rheumatic Diseases. 65:408–409.
  47. Chang, H.T. (2006) Subacute Human Spinal Cord Contusion: Few Lymphocytes and Many Macrophages. Spinal Cord (in press) on-line Epub 2/28.
  48. Kinghorn, K.J., Crowther, D.C., Sharp, L.K., Nerelius, C., Davis, R.L., Chang, H.T., Green, C., Gubb, D.C., Johansson, J., Lomas, D.A. (2006) Neuroserpin binds Ab and is a neuroprotective component of amyloid plaques in Alzheimer’s disease. J. Biol. Chem (in press).
  49. Ramachandran, T.S., Zachariah, S.B., Agrawal, V.K., Parikh, S.L., Swarnkar, A., Chang, H.T. (2006) "Alzheimer Disease." eMedicine Journal [serial online], at: http://www.emedicine.com/journalname/topic22.htm.
  50. Shah, S. Schelper, R.L., Krishnamurthy, S., Chang, H.T., (2006) A 11-year-old boy with an incidental mass in the left lateral cerebellum. Neuropathology (in press)

Book Chapters

  1. Kitai, S.T., Penny, G.R., Chang, H.T. (1989) Intracellular labeling and immunocytochemistry. In L. Heimer and L. Zaborszky (eds.) Neuroanatomical Tract-Tracing Methods II. Recent Progress Plenum Publishing Corporation, N.Y. pp 173-199.
  2. Chang, H.T., Wilson, C.J. (1990) Anatomical analysis of electrophysiologically characterized neurons in the rat strio-pallidal system. In A. Björklund, T. Hökfelt, F. Wouterlood and A.N. van den Pol (Ed.), Handbook of Chemical Neuroanatomy, vol. 8 "Methods for the Analysis of Neuronal Microcircuits", Elsevier, Amsterdam, pp. 351-402.
  3. Chang, H.T., Kuo, H. (1991) Calcium-binding protein (calbindin D-28k) immunoreactive neurons in the basal forebrain of the monkey and the rat: relationship with the cholinergic neurons. In P. Kalivas, I. Hanin, and T.C. Napier (eds.) "The Basal Forebrain", Plenum Press, N.Y. Adv. Exp. Med. Biol. 295:119-126.

Recent Abstracts

  1. Chang, H.T., Yang, D.Q., Tang, X.L., Wands, JR., de la Monte, S.M. (2001) Mitochondrial abnormalities in the fetal alcohol syndrome (FAS) J. Neuropath Exp Neurol. 60:558.
  2. Zipser, B.D., Berzin, T.M., Gur, T., Kuo-Lebanc, V., Hovanesian, G., Johanson, C.E., Chang, H.T., Hulette, C., Rosenberg, M.P., Viteck, M.P., Stopa, E.G. (2001) Blood-brain barrier integrity in Alzheimer’s disease. J. Neuropath Exp Neurol. 60:508.
  3. Cortez, S., Vonsattel, J.P., Stopa, E.G., Chang, H.T. (2001) Familial Pick’s’s disease without Pick’s bodies: a report of 2 cases with severe cerebral atrophy. J. Neuropath Exp Neurol. 60:547.
  4. Chang, H.T., Schelper, R.L., Krishnamurthy, S. (2002) Desmoplastic infantile ganglioglioma in a 15 month old girl: a case report. J. Neuropath Exp Neurol. 61:475.
  5. Schelper, R.L., Chang, H.T. (2002) Tanycytoma of the fourth ventricle of an adult. J. Neuropath Exp Neurol. 61:474.
  6. Chandan, V., Chang, J., Schelper, R.L., Chang, H.T. (2003), Foix-Alajouanine Disease (necrotizing myelopathy with vascular malformation in the lower spinal cord): A case report. J. Neuropath Exp Neurol. 62:568.
  7. Jung, S., Chang, H.T., Schelper, R.L. (2003) A case of Balamuthia mandrillaris encephalitis with unusual clinical course: a case report. J. Neuropath Exp Neurol. 62:562.
  8. Chandan, V., Hutchison, R.E., Schelper, R.L., Chang, H.T. (2004) Primary central nervous system T-cell lymphoma in a 33 year-old man: report of a case and review of the literature. J. Neuropath Exp Neurol. 63:545.
  9. Chang, H.T., Schelper, R.L., Latorre, J.G., Hahn, S. (2004) Cerebellar glioblastoma, pleomorphic xanthoastrocytoma, or desmoplastic infantile ganglioglioma? J. Neuropath Exp Neurol. 63:537.
  10. Chang, H.T., Jones, K.M. (2004) Human cauda equina: a morphometric analysis. J. Neuropath Exp Neurol. 63:531.
  11. Hahn, S.S., Schelper, R.L., Montgomery, C.T., Chang, H.T., Haq, R. (2004) Gamma knife radiosurgery (GKRS) related pathologic changes in a patient with metastatic non-small cell lung cancer (NSCLC). 12th International Meeting of Leksell Gamma Knife Soci
    12. ety (Vienna, Austria) in May, 2004.
  12. Schelper R.L., Landas, S.K., Chang, H.T. (2004) Tanycytoma of the spinal cord of an adult. J. Neuropath Exp Neurol. 63:536.
  13. Shah, S., Schelper, R.L., Chang, H.T. (2005) Pediatric cerebellar oligodendroglioma: report of a rare case and review of the literature. J. Neuropath Exp Neurol. 64:456.
  14. Chang, H.T., Schelper, R.L. (2005) Astrocyte atypia associated with gamma knife and whole brain radiation therapy. J. Neuropath Exp Neurol. 64:453.
  15. Chang, H.T., Holsapple, J.W., Souid, A.-K., Schelper, R.L. (2006) Malignant pediatric leptomeningeal oligodendrogliomatosis: a case report. Joint Meeting of the American Association of Neuropathologists and the International Congress of Neuropathologists, Brain Pathology (in press).
  16. Chang, H.T., Schelper, R.L. (2006) Human spinal cord injury research: a proposal for a consortium of tissue banks. Joint Meeting of the American Association of Neuropathologists and the International Congress of Neuropathologists, Brain Pathology (in press).
   
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