David Kaufman, D.O.
Professor and Chairman, Neurology

Academic Appointments

• 2000-present: Professor and Chair, Michigan State University, Neurology
• 1992-present: Medical Director: Sparrow Neurologic Centers of Excellence
• 1997-present:  Director, Neurology Osteopathic Residency Organization
• 1993-present:  Medical Director, Sparrow Hospital Neurosciences
• 1989-present:  Director, Consortium of Osteopathic Residencies in Ophthalmology
• 1998-2000: Professor and Director, Michigan State University, Center for Clinical Neuroscience and Ophthalmology
• 1996-2000: Professor, Michigan State University, Department of Physical Medicine and Rehabilitation (Neurology)
• 1994-1996: Associate Professor, Michigan State University, Department of Physical Medicine and Rehabilitation (Neurology)
• 1992-present: Medical Director: Sparrow Neurologic Centers of Excellence
• 1988-1994: Associate Professor, Michigan State University, Department of Internal Medicine (Neurology
• 1984-1988: Assistant Professor, Michigan State University, Department of Internal Medicine (Neurology)

Postdoctoral Training

• 1983-1984: Fellow in Clinical Neuro-Ophthalmology, Massachusetts General Hospital
• 1982-1983: Fellow in Clinical Neurophysiology, University of Wisconsin
• 1979-1982: Resident, University of Wisconsin, Neurology
• 1978-1979: Intern, Cherry Hill Medical Center

Education

• D.O., Philadelphia College of Osteopathic Medicine, 1978
• B.S., University of Wisconsin, Zoology and History, 1973

Research Interests

Typically we use the eye and optic nerve as a model to determine the effectiveness of treatment strategies with brain disease. Our center has had collaborations with the National Eye Institute to longitudinally follow the effects of steroid use in patients with optic neuritis and longitudinal follow-up of patients with Anterior Ischemic Optic Neuropathy.

We are also looking at the use of experimental drugs in patients with acute onset of stroke, Tamoxifen (anti-breast cancer medicine) affects on the eye, early treatment strategies in multiple sclerosis, and etc.

Representative Publications

Papers

• Kaufman DI, Trobe JD, Eggenberger ER, Whitaker JN. Practice Parameter: The Role of Corticosteroids in the Management of Acute Monosymptomatic Optic Neuritis. Neurology, 2000; 54:2039-2044.
• Eggenberger ER, Desai NP, Kaufman DI, Pless M. Internuclear Ophthalmoplegia After Coronary Artery Catheterization and Percutaneous Transluminal Coronary Balloon Angioplasty. Journal of Neuro-Ophthalmology 20(2): 123-126, 2000.
• Kaufman DI, Fratkin J. Clinical Challenges - Really Painful Double Vision (comments). Survey of Ophthalmology 45(2): 155-9, 2000.
• Eggenberger ER, Kaufman DI. Ocular Motility Review for 1997-1998: Part I. Journal of Neuro-Ophthalmology 20(2): 73-84, 2000.
• Eggenberger ER, Kaufman DI. Ocular Motility Review for 1997-1998: Part II. Journal of Neuro-Ophthalmology, 20(3): 192-206, 2000.
• Kaufman DI, Dickersin K, Newman N, Kelman S, et al. and the IONDT Research Group. Ischemic Optic Neuropathy Decompression Trial: Twenty-Four Month Update. Arch Ophthalmol, 2000; 118:793-798.
• Sacco RI, DeRosa JT, Haley EC, Levin B, and the GAIN Americas Investigators. Glycine Antagonist in Neuroprotection for Patients with Acute Stroke. JAMA, 2001; 285:1719-1728.
• Huang J, Cooper TG, Satana B, Kaufman DI, Cao, Y. Visual Distortion Provoked by a Stimulus in Migraine Associated with Hyperneuronal Activity. Headache. 2003;43:664-671.
• Smolyar A, Eggenberger ER, Kaufman DI. Monocular Temporal Hemianopia Associated with Optic Nerve Hypoplasia. Arch Ophthalmology. 2005:123; 1155.
• Kidd G, Hong H, Majid A, Kaufman DI, Chen AF. Inhibition of Brain GTP Cyclohydrolase I and Tetrahydrobiopterin Attenuates Cerebral Infarction via Reducing Inducible NO Synthase and Peroxynitrite in Ischemic Stroke. Stroke, 2005:36:2705-2711.
• Warach S, Kaufman D, Chiu D, Devlin T, Luby M, Rashid A, Clayton L, Kaste M, Lees KR, Sacco R, Fisher M. The effect of the glycine antagonist gavestinel on cerebral infarcts in acute stroke patients, a randomized-placebo controlled trial: The GAIN MRI substudy. Cerebrovascular Diseases, 2006:21:106-111.
• Hong H, Zeng J, Kreulen D, Kaufman D, Chen A. Atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived superoxide in ischemic stroke. Am J Physiol Heart Circ Physiol, 2006:291:2210-2215.
• Demidenko A, Vakili R, Eggenberger E, Kaufman D.  Late onset Leber’s Hereditary Optic Neuropathy.  NOPH Neuro-Ophthalmology.  In press 2008.

Book Chapters

• Kaufman, DI. Optic Nerve Disorders, Encyclopedia of the Neurological Sciences, (eds: Aminoff, M., and Daroff, R.) Vol. 3, pp. 686-690, Academic Press, San Diego, 2003.
• Kaufman, DI. Acute Monosymptomatic Optic Neuritis: Potential Clues to Early Therapy in Multiple Sclerosis. In: Early Indicators, Early Treatments, Neuroprotection in Multiple Sclerosis, Hommes OR and Comi G, Eds., pp. 155-162, Springer-Verlag Italia, Milan, 2004.
• Kaufman, DI, Eggenberger ER, co-Editors. In: Ophthalmology Clinics of North America, September 2004. Elsevier Inc.
• Kaufman DI. Ancillary Electrophysiologic Testing. In: Neuro-Ophthalmology The Practical Guide, Levin LA and Arnold AC eds., pp. 422-437, Thieme Medical Publishers, Inc. 2005.
• Kaufman DI and Eggenberger ER. Optic Nerve and Chiasm. In: Disorders of visual processing, Celesia G, ed. Elsevier, 2005.
• Kaufman DI. Peripheral Demyelinating and Axonal Disorders. In: Walsh and Hoyt’s Clinical Neuro-Ophthalmology Vol VI, Miller and Newman, eds, 2006.