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Faculty

Andrea Bozoki, M.D.Andrea Bozoki, M.D.
Associate Professor, Neurology

Academic Appointments

  • 2010 - present: Associate Professor, Michigan State University, Neurology
  • 2009 - present: Director, Geriatric and Cognitive Neurology, Michigan State University, Neurology
  • 2001-2010: Assistant Professor, Michigan State University, Neurology

Postdoctoral Training

  • 1999-2001: Fellow in Cognitive Neurology, University of Michigan
  • 1997-1999: Fellow in Geriatric Neurology, University of Michigan
  • 1994-1997: Resident, University of Michigan, Neurology
  • 1993-1994: Intern, Beth Israel Medical Center

Education

  • M.D., State University of New York, 1993
  • B.S., Biology, Cornell University, 1986

Dr. Bozoki graduated in 1993 from the State University of New York, Health Sciences Center at Brooklyn. She did an internship at Beth Israel Medical Center in Manhattan and then moved to the Midwest to pursue a residency in Neurology at the University of Michigan. She went on to do a 2 year clinical fellowship in Geriatric Neurology and then joined the Institute of Gerontology in order to obtain an additional 2 years of research training in memory disorders of aging and early Alzheimer’s disease, all at the University of Michigan. She was board-certified in 1998, and joined the faculty as an assistant professor in the Department of Neurology and Neuro-ophthalmology at Michigan State University in 2001 with admitting privileges at both Ingham Regional Medical Center and Sparrow Hospital.

Since joining the faculty of MSU in July 2001, she divides her time between clinical care of patients (specializing in neurologic dysfunctions of those over age 60) and research examining the effects of aging and dementia on memory networks of the brain using functional magnetic resonance imaging.

Research

My lab is currently focused on studying the memory deficits that occur during the transition from normal aging to Alzheimer's disease (AD). We are studying 3 groups of individuals; healthy seniors, those with Mild Cognitive Impairment (a diagnosis that encompasses both memory-predominant and other-cognitive predominant deficits that are not severe enough to be considered dementia) and those with early stage AD. We are using event-related fMRI to visualize neural network differences between successful and unsuccessful learning attempts, both within and across groups. An offshoot of this work is a study examining the differences between rapid presentation of to-be-remembered stimuli (every 2.5 - 7.5 sec) versus traditional event-related presentation timing (every 15 sec). This latter study is being performed in a population of young (college-age) subjects.

The second focus of the lab is the use of a method known as DTI, which allows for evaluation of the integrity of white matter tracts. It has been established that fractional anisotropy (a measure of water diffusion along a vector) is decreased during aging in several major pathways (ie corpus callosum). It is the intention of this work to delineate whether the fornix (the main outflow pathway from the hippocampal complex) shows similar changes during aging, and could be used as a marker early in the process of converting to AD.

Please feel free to contact me if you have any questions about my research: andrea.bozoki@ht.msu.edu

Selected Publications

  • Bozoki A, An H, Bozoki ES, Little R. The Existence of Cognitive Plateaus in Alzheimer Disease. Alzheimer’s & Dementia, 2009; 5(6):470-478
  • Delano-Wood L, Bondi MW, Sacco J, Abeles N, Jak AJ, Libon DJ, Bozoki A.  Heterogeneity in Mild Cognitive Impairment:  Differences in Neuropsychological Profile and Associated White Matter Lesion Pathology. Journal of the International Neuropsychological Society, 2009; 15(6):906-914
  • An H, Little R, Bozoki A. A Statistical Algorithm for Detecting Cognitive Plateaus in Alzheimer's Disease. Journal of Applied Statistics, 2010; 37(5):779-789
  • Bozoki A, Farooq MU. Frontotemporal Dementia: insights from neuropsychology and neuroimaging. International Review of Neurobiology, 2009; 84:185-213
  • Delano-Wood L, Abeles N, Sacco JM, Wierenga CE, Horne NR, Weerappui P, Delano M, Murman D, Bozoki A. Regional white matter pathology in Mild Cognitive Impairment: differential influence of lesion type on neuropsychological functioning. Stroke, 2008; 39(3): 794-9
  • Bozoki A, Smith EE, Grossman M. Can Patients with Alzheimer’s Disease Learn a Category Implicitly? Neuropsychologia, 2006; 44(5):816-27
  • Bozoki A, Giordani B, Heidebrink JL, Berent S, Foster NL. Mild Cognitive Impairments Predict Dementia in Non-demented Elderly with Memory Loss. Archives of Neurology, 2001; 58(3): p411-416
  • Bozoki A, An H, Foster NL, Giordani B and Little RJ. (2002). Are There Cognitive Plateaus in Alzheimer's Disease? Abstract. Brain Aging 2 (3 suppl.)
  • Bozoki A, Delano MC, Potchen M, Huang J. Diffusion Tensor imaging of the fornix in Alzheimer’s disease. Abstract. Neurology 2004; 62(7 Suppl. 5): A126
  • Bozoki A, Purcell JJ, Zacks R, Delano MC, Symonds L. Event-related fMRI of visual encoding and recognition. Abstract. Cognitive Neuroscience Society annual meeting 2004; 11(Suppl. 1):72
  • Bozoki A, Purcell JJ, Zacks R, Delano MC, Symonds L. A Comparison of two methods for obtaining event-related fMRI data. Abstract. Neuroimage 2004; 22(Suppl. 1): S22-S60
  • Purcell JJ, Bozoki A, Zacks R, DeLano MC, Symonds LL. Brain Regions Associated with Correct Identification of Old and New Stimuli. Cognitive Neuroscience Society Annual Meeting / New York, NY / April 15 – 19, 2005
   
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